连续流和分段流微流体技术：在高通量化学和生物学中的应用

Continuous and segmented flow microfluidics: applications in high-throughput chemistry and biology.

作者信息

Stanley Claire E, Wootton Robert C R, deMello Andrew J

机构信息

Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zürich, Zürich, Switzerland.

出版信息

Chimia (Aarau). 2012;66(3):88-98. doi: 10.2533/chimia.2012.88.

DOI:10.2533/chimia.2012.88

PMID:22546251

Abstract

This account highlights some of our recent activities focused on developing microfluidic technologies for application in high-throughput and high-information content chemical and biological analysis. Specifically, we discuss the use of continuous and segmented flow microfluidics for artificial membrane formation, the analysis of single cells and organisms, nanomaterial synthesis and DNA amplification via the polymerase chain reaction. In addition, we report on recent developments in small-volume detection technology that allow access to the vast amounts of chemical and biological information afforded by microfluidic systems.

摘要

本报告重点介绍了我们近期的一些活动，这些活动专注于开发微流控技术，以应用于高通量和高信息量的化学及生物分析。具体而言，我们讨论了连续流和分段流微流控技术在人工膜形成、单细胞和生物体分析、纳米材料合成以及通过聚合酶链反应进行DNA扩增方面的应用。此外，我们还报告了小体积检测技术的最新进展，这些进展使得能够获取微流控系统所提供的大量化学和生物信息。