Ohno Ken-ichi, Tachikawa Kaoru, Manz Andreas
Institute for Analytical Sciences, Dortmund, Germany.
Electrophoresis. 2008 Nov;29(22):4443-53. doi: 10.1002/elps.200800121.
In this review, we present recent advancements and novel developments in fluidic systems for applied analytical purposes in chemistry, biochemistry, and life science in general that employ and reflect the full benefits of microfluidics. A staggering rise in publications related to integrated, all-in-one microfluidic chips capable of separation, reaction, and detection have been observed, all of which realise the principal of micro total analysis systems or lab-on-a-chip. These integrated chips actively adopt the scaling law concepts, utilising the highly developed fabrication techniques. Their aim is to multi-functionalise and fully automate devices believed to assist the future advancements of point-of-care, clinical, and medical diagnostics.
在本综述中,我们介绍了流体系统在化学、生物化学及一般生命科学领域应用分析方面的最新进展和新发展,这些流体系统采用并体现了微流控技术的全部优势。我们观察到,与能够进行分离、反应和检测的集成一体化微流控芯片相关的出版物数量惊人地增长,所有这些芯片都实现了微全分析系统或芯片实验室的原理。这些集成芯片积极采用缩放定律概念,利用高度发达的制造技术。其目标是使设备多功能化并实现完全自动化,相信这将有助于即时护理、临床和医学诊断的未来发展。