Kramer M S, MacLellan A M, Ciampi A, Etezadi-Amoli J, Leduc D G
Department of Pediatrics, McGill University Faculty of Medicine, Montreal, Quebec, Canada.
J Clin Epidemiol. 1990;43(12):1319-25. doi: 10.1016/0895-4356(90)90098-a.
Our previous analyses of decision strategies in children 3-24 months with acute-onset fever greater than or equal to 39 degrees C and no evident bacterial focus of infection indicated that the risks of routine blood cultures (the unnecessary hospitalization and treatment of children who clear their bacteremia spontaneously) outweigh its benefits (the prevention of a few cases with major infectious sequelae). Because those analyses were based on parents' values for beneficial and adverse clinical outcomes, we wished to examine whether those values differed in physicians and, if so, whether the differences were sufficient to change the results of the decision analysis. Using a pre-tested linear analog utility (value) scale, we evaluated eight potential clinical outcomes in potentially bacteremic children by surveying 121 parents of healthy 3-24-month-old children attending a private pediatric group practice and 57 attending physicians of a tertiary-care children's hospital emergency room. Utilities were based on a 0-1 normalization, where 0 is the utility of the worst outcome (meningitis or other major bacterial infection, plus venipuncture), and 1 the utility of the best outcome (complete recovery without venipuncture or hospitalization), and were analyzed using a recently developed statistical model of utility. The majority of parents and physicians combined the imputed components of the outcomes (disease, pain of venipuncture, and stress of hospitalization) in a nonlinear fashion. Parents assigned substantially lower utility (i.e. greater disutility) to venipuncture, minor infection, and hospitalization than did physicians, and these utilities were even lower in parents with other children at home.(ABSTRACT TRUNCATED AT 250 WORDS)
我们之前对3至24个月急性发热且体温大于或等于39摄氏度、无明显细菌感染病灶儿童的决策策略分析表明,常规血培养的风险(即对那些能自发清除菌血症的儿童进行不必要的住院和治疗)超过了其益处(预防少数出现严重感染后遗症的病例)。由于这些分析基于家长对有利和不利临床结果的价值观,我们希望研究这些价值观在医生中是否不同,如果不同,这些差异是否足以改变决策分析的结果。我们使用预先测试的线性模拟效用(价值)量表,通过调查一家私立儿科诊所中121名健康的3至24个月大儿童的家长以及一家三级儿童专科医院急诊室的57名主治医生,评估了可能患有菌血症儿童的八种潜在临床结果。效用基于0至1的标准化,其中0是最差结果(脑膜炎或其他主要细菌感染,加上静脉穿刺)的效用,1是最佳结果(无需静脉穿刺或住院即可完全康复)的效用,并使用最近开发的效用统计模型进行分析。大多数家长和医生以非线性方式综合了结果的估算组成部分(疾病、静脉穿刺疼痛和住院压力)。家长对静脉穿刺、轻微感染和住院的效用赋值显著低于医生,而家中还有其他孩子的家长的这些效用值更低。(摘要截短于250字)