Cohen R E, Cardoza T T, Drinnan A J, Aguirre A, Neiders M E
Department of Periodontology, School of Dental Medicine, State University of New York, Buffalo.
J Periodontol. 1990 Nov;61(11):705-9. doi: 10.1902/jop.1990.61.11.705.
Localized Wegener's granulomatosis is characterized by necrotizing granulomatous disease affecting the upper and lower respiratory tracts, mucosa, and skin. Without treatment, disseminated necrotizing vasculitis and focal necrotizing glomerulonephritis usually follow. Although oral lesions are relatively common, they have been infrequently described and have rarely been reported as the sole manifestation of this disease. In this report, we present two cases of early Wegener's granulomatosis which featured hyperplastic gingival lesions as the initial presenting lesion. Clinical findings and histological evaluation of tissue obtained from the gingival lesion following incisional and excisional biopsies supported the diagnosis of Wegener's granulomatosis. These cases illustrate that less-frequently occurring entities should be considered in the differential diagnosis of localized gingival lesions which fail to respond to conventional therapy.
局限性韦格纳肉芽肿病的特征是坏死性肉芽肿性疾病，累及上、下呼吸道、黏膜和皮肤。未经治疗，通常会继发播散性坏死性血管炎和局灶性坏死性肾小球肾炎。虽然口腔病变相对常见，但对其描述较少，很少有报道称其为此病的唯一表现。在本报告中，我们呈现了两例早期韦格纳肉芽肿病，其最初表现为增生性牙龈病变。切开活检和切除活检后从牙龈病变获取的组织进行的临床检查和组织学评估支持韦格纳肉芽肿病的诊断。这些病例表明，对于对传统治疗无反应的局限性牙龈病变进行鉴别诊断时，应考虑较少见的疾病实体。
