Wolff-Kormann P G, Stefani F H, Riedel K G
Universitäts-Augenklinik, München.
Fortschr Ophthalmol. 1990;87(5):488-91.
Wegener's granulomatosis is characterized by necrotizing granulomatous vasculitis that initially occurs in a localized form, disseminates in various degrees and particularly involves the respiratory tract and kidneys. Eye manifestations are common (40 to 60%). Both clinical and histopathological findings are described in eight patients with Wegener's granulomatosis. The initial ocular symptoms included conjunctivitis, episcleritis, scleritis, corneoscleral ulceration, uveitis and ocular proptosis. In one patient histological examination of the orbital tissue was consistent with limited Wegener's granulomatosis 6 years before generalized granulomatous vasculitis confirmed the underlying disease. As new diagnostic and therapeutic modalities (detection of antineutrophil cytoplasmatic autoantibodies and therapy with trimethoprim-sulfamethoxazole) exist, a knowledge of the ocular initial symptoms of Wegener's granulomatosis can have considerable significance.
韦格纳肉芽肿病的特征是坏死性肉芽肿性血管炎，最初以局部形式出现，不同程度地播散，尤其累及呼吸道和肾脏。眼部表现很常见（40%至60%）。本文描述了8例韦格纳肉芽肿病患者的临床和组织病理学发现。最初的眼部症状包括结膜炎、巩膜外层炎、巩膜炎、角膜巩膜溃疡、葡萄膜炎和眼球突出。1例患者眼眶组织的组织学检查在全身性肉芽肿性血管炎确诊潜在疾病6年前符合局限性韦格纳肉芽肿病。由于存在新的诊断和治疗方法（抗中性粒细胞胞浆自身抗体检测和甲氧苄啶-磺胺甲恶唑治疗），了解韦格纳肉芽肿病的眼部初始症状可能具有相当重要的意义。
