Bartold P M, Henning F R
Department of Pathology, University of Adelaide, Australia.
J Periodontol. 1990 Nov;61(11):710-3. doi: 10.1902/jop.1990.61.11.710.
A patient with a previous medical history of immunoproliferative small intestinal disease (IPSID) presented with persistent red and ulcerated lesions on her attached gingiva. Despite the obvious long standing gingival inflammation, minimal destruction of alveolar bone had occurred. Following failure of the tissues to respond to routine periodontal therapy, a gingival biopsy was taken. Histological assessment of the specimen revealed several features in common with the intestinal lesions seen in IPSID. In particular, a large plasma cell infiltrate subjacent to the gingival epithelium was noted. There was a marked loss of normal connective tissue morphology and evidence of epithelial degeneration. Treatment has since consisted of palliative measures only. While this is a relatively rare condition, it (as well as other disorders of the immune system) provides a useful insight into the role that the immune system plays in the inflammatory periodontal diseases.
一名既往有免疫增殖性小肠疾病（IPSID）病史的患者，其附着龈出现持续性红色溃疡病变。尽管存在明显的长期牙龈炎症，但牙槽骨仅有轻微破坏。在组织对常规牙周治疗无反应后，进行了牙龈活检。标本的组织学评估显示出一些与IPSID肠道病变相同的特征。特别是，在牙龈上皮下方观察到大量浆细胞浸润。正常结缔组织形态明显丧失，并有上皮变性的证据。此后的治疗仅采取了姑息措施。虽然这是一种相对罕见的疾病，但它（以及其他免疫系统疾病）为免疫系统在炎症性牙周病中所起的作用提供了有益的见解。
