UMR1027, INSERM, Université de Toulouse, Toulouse, France.
Oral Dis. 2012 Nov;18(8):748-55. doi: 10.1111/j.1601-0825.2012.01940.x. Epub 2012 May 1.
Poor oral health has previously been related to high body mass index (BMI). We aimed at exploring the link between BMI and several oral health markers, after adjustment for dietary patterns and plasma insulin, both of which could act as mediators.
Dental examination was performed in a sample of 186 French subjects aged 35-64 years and selected from the general population to assess number of missing teeth, periodontitis, clinical attachment loss (CAL), probing pocket depth (PD), gingival index (GI) and plaque index (PI). Data collection also included a food-frequency questionnaire. BMI (considered as outcome variable) was categorized into quartiles, and as BMI<25; 25 ≤BMI<30; and BMI ≥ 30 kg m(-2) .
After adjustment for age, gender, education level, smoking, physical activity, energy intake and C-reactive protein, BMI was statistically associated with missing teeth, PD and PI, but not with CAL, GI or periodontitis. After additional adjustment for 'high-carbohydrate' diet and plasma insulin or HOMA (homeostasis model assessment) index for insulin resistance, the statistical relationship between BMI and oral variables remained significant only for PD and PI.
Plaque index, reflecting dental plaque, and PD, closely linked with periodontal inflammation and infection, are statistically associated with high BMI and obesity, independently of dietary patterns and insulin resistance.
先前的研究表明，口腔健康状况不佳与身体质量指数（BMI）高有关。我们旨在探讨 BMI 与几种口腔健康指标之间的关系，这些指标在调整饮食模式和血浆胰岛素后仍然存在关联，因为这两者都可能作为中介因素。
在一个年龄在 35-64 岁的法国人群样本中进行了口腔检查，该样本是从一般人群中选择的，以评估缺失牙的数量、牙周炎、临床附着丧失（CAL）、探诊袋深度（PD）、牙龈指数（GI）和菌斑指数（PI）。数据收集还包括一份食物频率问卷。BMI（作为因变量）分为四组，分别为 BMI<25；25 ≤BMI<30；和 BMI ≥ 30 kg/m²。
在调整了年龄、性别、教育水平、吸烟、身体活动、能量摄入和 C 反应蛋白后，BMI 与缺失牙、PD 和 PI 呈统计学相关，但与 CAL、GI 或牙周炎无关。在进一步调整“高碳水化合物”饮食和血浆胰岛素或胰岛素抵抗的稳态模型评估（HOMA）指数后，BMI 与口腔变量之间的统计学关系仅在 PD 和 PI 上仍然显著。
反映牙菌斑的菌斑指数和 PD 与牙周炎和感染密切相关，与高 BMI 和肥胖相关，独立于饮食模式和胰岛素抵抗。
