Division of Parasitology, MRC National Institute for Medical Research, London, United Kingdom.
Int J Parasitol. 2012 May 15;42(6):549-55. doi: 10.1016/j.ijpara.2012.03.010. Epub 2012 Apr 24.
Despite intense research, malaria still is the one of the most devastating diseases killing more people than any other parasitic infection. In an attempt to control the infection, the host immune system produces a potent pro-inflammatory response. However, this response is also associated with complications, such as severe anaemia, hypoglycaemia and cerebral malaria. This pronounced production of pro-inflammatory cytokines response is a common feature of malaria caused by parasites infecting humans as well as rodents and primates. A balance between pro- and anti-inflammatory responses may be fundamental to the elimination of the parasite without inducing excessive host pathology. IL-10 is a key cytokine that has been shown to have an important regulatory function in establishing this balance in malaria. Here we discuss which cells can produce IL-10 during infection, and present an overview of the evidence showing that T-cell derived IL-10 plays an important role in regulating malaria pathology. Many different subsets of T cells can produce IL-10, however, evidence is accumulating that it is effector Th1 CD4(+) T cells which provide the crucial source that down-regulates inflammatory pathology during blood-stage malaria infections.
尽管进行了深入研究，但疟疾仍然是最具破坏性的疾病之一，其致死人数超过任何其他寄生虫感染。为了控制感染，宿主的免疫系统会产生强烈的促炎反应。然而，这种反应也与严重贫血、低血糖和脑型疟疾等并发症有关。这种促炎细胞因子的强烈产生是由寄生虫感染人类以及啮齿动物和灵长类动物引起的疟疾的共同特征。促炎和抗炎反应之间的平衡对于在不引起宿主过度病理的情况下消除寄生虫可能是至关重要的。IL-10 是一种关键的细胞因子，已被证明在疟疾中具有重要的调节功能，以建立这种平衡。在这里，我们讨论了在感染过程中哪些细胞可以产生 IL-10，并概述了表明 T 细胞衍生的 IL-10 在调节疟疾病理方面发挥重要作用的证据。许多不同的 T 细胞亚群都可以产生 IL-10，但是越来越多的证据表明，效应性 Th1 CD4(+) T 细胞是在红细胞期疟疾感染期间下调炎症病理的关键来源。
