七配位钛（IV）-双螯合物的合成及 X 射线结构分析及其增强的体内抗肿瘤疗效。
Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy.
机构信息
Fachbereich Chemie and Konstanz Research School Chemical Biology, Universität Konstanz, Universitätsstr. 10, D-78457 Konstanz, Germany.
出版信息
Chem Commun (Camb). 2012 Jun 11;48(46):5790-2. doi: 10.1039/c2cc31624b. Epub 2012 May 1.
PMID:22549385
Abstract
Chelate stabilization of a titanium(IV)-salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.
摘要
通过与 2,6-吡啶二甲酸（dipic）的配体交换，螯合物稳定了钛（IV）-salan 烷氧化物，得到了七配位配合物 3，它没有氧化还原活性，在硅胶上稳定，并且增加了水相稳定性。3 在 HeLa S3 和 Hep G2 中具有高毒性，并在小鼠宫颈癌模型中增强了抗肿瘤功效。
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