Rohde Max, Grøntved Ågo Møller, Krogdahl Annelise, Godballe Christian
Department of ENT Head & Neck Surgery, Odense University Hospital, Odense, Denmark.
Dan Med J. 2012 May;59(5):A4399.
Several studies show that early histological classification and excision of precancerous lesions of the vocal cords reduces the risk of cancer development. National Danish guidelines have not been established. The purpose of this study was to describe a Danish series of patients with precancerous lesions of the vocal cords and to estimate the risk of malignant transformation.
This was a retrospective cohort study, including a total of 101 patients with histologically verified precancerous lesions of the vocal cords who were treated from 1997 to 2007 at Odense University Hospital (OUH).
Among the 101 patients, 18 (18%) were diagnosed with mild dysplasia, 16 (16%) with moderate dysplasia, 35 (35%) with severe dysplasia and 32 (32%) with carcinoma in situ (CIS) at the initial examination at OUH. Fifteen patients (15%), all males, developed invasive cancer. Among these, one patient was initially diagnosed with mild dysplasia, one with moderate dysplasia, seven with severe dysplasia and six with CIS. In 11 of the 15 patients (73%), cancer occurred within one year from the time of diagnosis of the precancerous lesion, whereas four cancers occurred years later.
The malignant transformation rate is comparable with other recent series. A strategy with elimination of all visible pathology is preferable.
not relevant.
not relevant.
多项研究表明，早期对声带癌前病变进行组织学分类并切除可降低癌症发生风险。丹麦尚未制定国家指南。本研究旨在描述丹麦一组声带癌前病变患者，并评估其恶变风险。
这是一项回顾性队列研究，共纳入101例经组织学证实的声带癌前病变患者，这些患者于1997年至2007年在欧登塞大学医院（OUH）接受治疗。
在这101例患者中，初次在OUH检查时，18例（18%）被诊断为轻度发育异常，16例（16%）为中度发育异常，35例（35%）为重度发育异常，32例（32%）为原位癌（CIS）。15例患者（15%），均为男性，发生了浸润性癌。其中，1例患者最初被诊断为轻度发育异常，1例为中度发育异常，7例为重度发育异常，6例为原位癌。在这15例患者中的11例（73%），癌症在癌前病变诊断后1年内发生，而4例癌症在数年后发生。
恶变率与其他近期系列研究相当。最好采用消除所有可见病变的策略。
无关。
无关。
