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将个性化医学“传送”至现实：血液中的突变检测。

BEAMing up personalized medicine: mutation detection in blood.

机构信息

Department of Pathology and Surgery, Brigham and Women's Hospital; Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA.

出版信息

Clin Cancer Res. 2012 Jun 15;18(12):3209-11. doi: 10.1158/1078-0432.CCR-12-0871. Epub 2012 May 1.

DOI:10.1158/1078-0432.CCR-12-0871
PMID:22550168
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3377838/
Abstract

BEAMing is a feasible, accurate, and sensitive method for detection of PIK3CA mutations in circulating tumor DNA in blood. Mutation status of PIK3CA may change between primary tumor and recurrence. The results suggest a new approach for noninvasive determination of current mutation status in patients with metastatic disease.

摘要

BEAMing 是一种在血液循环肿瘤 DNA 中检测 PIK3CA 突变的可行、准确和敏感的方法。PIK3CA 的突变状态可能在原发肿瘤和复发之间发生变化。这些结果表明了一种新的方法，可以在转移性疾病患者中进行非侵入性的当前突变状态的检测。

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本文引用的文献

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Clin Cancer Res. 2012 Jun 15;18(12):3462-9. doi: 10.1158/1078-0432.CCR-11-2696. Epub 2012 Mar 15.
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