Iordanishvili A K, Soldatov S V, Moskalev A V, Soldatova L N, Ryzhak G A
Adv Gerontol. 2011;24(4):685-91.
The microbiocenosis of periodontal recesses was studied and an assessment of the innate immunity mechanisms, as well as profiles of inflammatory cytokines were carried out in 114 people of middle, elderly and senile age with chronic generalized periodontitis (CGP). It was found that periodontal recesses mikrobiocenosis of patients with CGP of various ages was mainly presented by conditionally pathogenic bacterial and fungal microflora. There were identified the inefficient mechanisms of immune inflammation in case of conditionally pathogenic microflora, the reduction of neutrophils functional properties, and the increasing part of destructed phagocytazing neutrophils in patients of elderly and senile age. The immunosuppression in patients of elderly and senile age appears in insufficient production of IL-1beta, IL-8, resulting in reduced activity of phagocytosis mechanisms and lymphoid cells functional activity. Thus, the differences in etiopatogenetic microflora, immune homeostasis status in patients with CGP in middle, elderly and senile age, complexity in the application of antibacterial drugs require the development of new criteria for the selection of antibacterial drugs.
对114名患有慢性广泛性牙周炎（CGP）的中青年、老年和高龄人群的牙周袋微生物群落进行了研究，并对其先天免疫机制以及炎性细胞因子谱进行了评估。结果发现，不同年龄段CGP患者的牙周袋微生物群落主要由条件致病性细菌和真菌菌群构成。已确定在存在条件致病性微生物群的情况下免疫炎症机制效率低下，老年和高龄患者中性粒细胞功能特性降低，以及被破坏的吞噬性中性粒细胞比例增加。老年和高龄患者的免疫抑制表现为IL-1β、IL-8产生不足，导致吞噬机制活性降低和淋巴细胞功能活性下降。因此，CGP患者在中青年、老年和高龄阶段的病因微生物群、免疫稳态状态存在差异，抗菌药物应用的复杂性要求制定新的抗菌药物选择标准。
