Yao Henry Han-I, Sengupta Shomik, Chee Justin
Department of Urology, Eastern Health, Melbourne, Australia.
Department of Urology, Western Health, Melbourne, Australia.
Transl Androl Urol. 2020 Dec;9(6):3195-3209. doi: 10.21037/tau.2019.08.07.
Penile cancer is a rare malignancy with a reported incidence of 0.66-1.44 per 100,000 men, and a reported mortality of 0.15-0.37 per 10,000 men. Expert clinical examination and histological diagnosis from biopsy is required to determine the extent and invasion of disease, which is paramount in planning of appropriate treatment. Management of loco-regional penile cancer can be divided into management of primary tumour and management of regional lymph nodes. This review article will focus on the management of the primary penile tumour with particular focus on penile sparing therapies. The aim of primary penile tumour management is to completely remove the tumour whilst preserving as much organ function as possible. Preservation of the penis is important as it allows patients to maintain urinary and sexual function, as well as quality of life. With the majority of penile cancer confined to the glans and foreskin, most penile cancers can be managed with organ-preserving therapy. A wide variety of treatment options are available, and this review aims to describe each of the options including the reported oncological and functional outcome for the different therapies for penile cancer.
阴茎癌是一种罕见的恶性肿瘤，据报道发病率为每10万名男性中有0.66 - 1.44例，死亡率为每1万名男性中有0.15 - 0.37例。需要通过专业的临床检查和活检的组织学诊断来确定疾病的范围和浸润情况，这对于制定合适的治疗方案至关重要。局部阴茎癌的治疗可分为原发性肿瘤的治疗和区域淋巴结的治疗。这篇综述文章将重点关注原发性阴茎肿瘤的治疗，尤其关注保留阴茎的治疗方法。原发性阴茎肿瘤治疗的目的是在尽可能保留器官功能的同时完全切除肿瘤。保留阴茎很重要，因为它能让患者维持排尿和性功能以及生活质量。由于大多数阴茎癌局限于龟头和包皮，大多数阴茎癌可以采用保留器官的治疗方法。有多种治疗选择，本综述旨在描述每种选择，包括不同阴茎癌治疗方法所报道的肿瘤学和功能结果。
