Kagal Urmila A, Torgal Shashikant S, Patil Nanasaheb M, Malleshappa Anil
Department of Pharmacology, KLE University's, Jawaharlal Nehru Medical College, Nehrunagar, Belgaum, Karnataka, India.
J Pharm Pract. 2012 Jun;25(3):368-73. doi: 10.1177/0897190012442220. Epub 2012 May 2.
The present study was taken up to assess the prevalence of the metabolic syndrome in schizophrenic patients receiving second-generation antipsychotic agents and to determine the most sensitive and specific clinical parameters used for screening of metabolic syndrome in these patients.
The present study was taken up in a tertiary care hospital. Eighty patients diagnosed with schizophrenia and receiving a single second-generation antipsychotic for 3 months or more were enrolled in the study after obtaining written informed consent. Patients were screened for metabolic syndrome using American Heart Association and National, Heart, Lung and Blood Institute (AHA NHLBI)-modified National Cholesterol Education Program, Adult Treatment Panel III (NCEP ATP III) criteria.
Prevalence of metabolic syndrome was found to be 35%. The clinical parameter with highest sensitivity for screening of metabolic syndrome is low-serum high-density lipoprotein cholesterol with a sensitivity of 89.28%. Elevated fasting blood glucose and increased waist circumference were found to have highest and equal specificity of 90.38%.
There is a high prevalence of the metabolic syndrome in patients with schizophrenic patients receiving second-generation antipsychotic agents. Increasing awareness of this fact among psychiatrists will help to prevent, detect, and treat this condition that is associated with considerable morbidity and mortality.
开展本研究以评估接受第二代抗精神病药物治疗的精神分裂症患者代谢综合征的患病率，并确定用于筛查这些患者代谢综合征的最敏感和特异的临床参数。
本研究在一家三级护理医院进行。在获得书面知情同意后，80例被诊断为精神分裂症且接受单一第二代抗精神病药物治疗3个月或更长时间的患者被纳入研究。使用美国心脏协会和美国国立心肺血液研究所（AHA NHLBI）修订的美国国家胆固醇教育计划成人治疗小组第三次报告（NCEP ATP III）标准对患者进行代谢综合征筛查。
发现代谢综合征的患病率为35%。筛查代谢综合征敏感性最高的临床参数是血清高密度脂蛋白胆固醇降低，敏感性为89.28%。空腹血糖升高和腰围增加的特异性最高且相等，均为90.38%。
接受第二代抗精神病药物治疗的精神分裂症患者中代谢综合征的患病率较高。精神科医生提高对这一事实的认识将有助于预防、检测和治疗这种与相当高的发病率和死亡率相关的疾病。
