Department of Neurosurgery, University of Texas Medical Branch, Galveston, TX, USA.
J Clin Neurosci. 2012 Jul;19(7):1055-7. doi: 10.1016/j.jocn.2012.01.003. Epub 2012 Apr 30.
Intracranial germinoma, a radiosensitive tumor, is seldom recurrent following initial treatment. When it does recur, it is usually soon after initial treatment and secondary to inadequate radiation field coverage of the tumor. Rarely, there have been case reports of late recurrence many years after initial therapy. Patients with recurrent germinoma in the spine have a less favorable prognosis in terms of treatment response compared to the initial lesion. Thus, careful consideration of the initial lesion, its treatment, and serial imaging of the neural axis with close follow-up is important. We report a patient with a rare delayed recurrence in the brain and cervical spinal cord despite close follow-up with clinical examination and serial imaging.
颅内生殖细胞瘤是一种对放疗敏感的肿瘤，初始治疗后很少复发。当复发时，通常是在初始治疗后不久，这是由于肿瘤的放射野覆盖不足。罕见情况下，有报道称初始治疗多年后出现迟发性复发。与初始病变相比，脊柱生殖细胞瘤复发患者的治疗反应预后较差。因此，仔细考虑初始病变、治疗以及密切随访的中枢神经系统影像学检查非常重要。我们报告了一例罕见的延迟性脑和颈段脊髓复发病例，尽管进行了密切的临床检查和连续影像学随访。
