健康儿童口咽部囊性纤维化病原体的流行情况及其对囊性纤维化治疗的影响。
Prevalence of cystic fibrosis pathogens in the oropharynx of healthy children and implications for cystic fibrosis care.
机构信息
Division of Pulmonary Medicine, Seattle Children's Hospital, Seattle, WA 98105, USA.
出版信息
J Cyst Fibros. 2012 Sep;11(5):456-7. doi: 10.1016/j.jcf.2012.04.004. Epub 2012 Apr 30.
OBJECTIVE
To describe the prevalence of the CF pathogens Pseudomonas aeruginosa, Staphylococcus aureus and Haemophilus influenzae in OP cultures from healthy children.
METHODS
Oropharyngeal (OP) swabs were collected from 100 healthy children ≤18 years of age undergoing a clinically indicated procedure.
RESULTS
P. aeruginosa was isolated from the OP swab of one participant, S. aureus from 48 participants (including 4 methicillin-resistant) and H. influenzae from 47 participants. Cultures from 75 participants grew one or more of these organisms (55 grew one, 19 grew 2 and one grew 3 organisms).
CONCLUSION
P. aeruginosa is rarely recovered from the oropharynx of healthy children ≤18 years of age, while recovery of S. aureus and H. influenzae is common. It is important to understand what the "normal" prevalence of CF pathogens is in the oropharynx in order to aid interpretation of OP cultures in CF patients.
目的
描述健康儿童口咽（OP）培养物中铜绿假单胞菌、金黄色葡萄球菌和流感嗜血杆菌 CF 病原体的流行情况。
方法
采集 100 名≤18 岁因临床指征而接受手术的健康儿童的咽拭子。
结果
1 名参与者的 OP 拭子中分离出铜绿假单胞菌，48 名参与者（包括 4 名耐甲氧西林）中分离出金黄色葡萄球菌，47 名参与者中分离出流感嗜血杆菌。75 名参与者的培养物中生长出一种或多种这些生物体（55 名生长出一种，19 名生长出两种，1 名生长出三种生物体）。
结论
铜绿假单胞菌很少从≤18 岁的健康儿童的口咽中分离出来，而金黄色葡萄球菌和流感嗜血杆菌的分离则很常见。了解 CF 患者 OP 培养物中 CF 病原体的“正常”流行情况很重要，以便帮助解释 OP 培养物。
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