巴西巴伊亚州囊性纤维化患者的病原体流行情况。
Prevalence of pathogens in cystic fibrosis patients in Bahia, Brazil.
作者信息
Santana Maria Angélica, Matos Eliana, do Socorro Fontoura Maria, Franco Rosana, Barreto Danyella, Lemos Antônio Carlos M
机构信息
Octávio Mangabeira Hospital, Centre of Cystic Fibrosis Reference of Bahia, Salvador, BA, Brazil.
出版信息
Braz J Infect Dis. 2003 Feb;7(1):69-72. doi: 10.1590/s1413-86702003000100008.
INTRODUCTION
Recurrent respiratory infections account for most of the morbidity and mortality of cystic fibrosis patients.
MATERIALS AND METHODS
The objective was to determine the prevalence of pathogens isolated from lower respiratory tract secretions in cystic fibrosis patients. In this descriptive observational study, data from 69 patients was collected from medical records.
RESULTS
The microorganisms that were identified included 36.2 P. aeruginosa, 28.9% S. Aureus, 4.3% K. pneumoniae, 1.5% H. influenzae, 1.5% E. coli, 1.5% S. maltoophilia, and in 27.5% the flora was normal. The prevalence of P. aeruginosa was 83% in patients under two years of age, demonstrating early colonization.
CONCLUSION
P. aeruginosa and S. aureus were the most prevalent pathogens; there was also early infection/colonization by P. aeruginosa. This information will contribute to improved therapeutic measures for patients of the Bahia Cystic Fibrosis Reference Center.
引言
反复呼吸道感染是囊性纤维化患者发病和死亡的主要原因。
材料与方法
目的是确定囊性纤维化患者下呼吸道分泌物中分离出的病原体的患病率。在这项描述性观察研究中，从病历中收集了69例患者的数据。
结果
鉴定出的微生物包括36.2%的铜绿假单胞菌、28.9%的金黄色葡萄球菌、4.3%的肺炎克雷伯菌、1.5%的流感嗜血杆菌、1.5%的大肠杆菌、1.5%的嗜麦芽窄食单胞菌，27.5%的患者菌群正常。两岁以下患者铜绿假单胞菌的患病率为83%，表明早期定植。
结论
铜绿假单胞菌和金黄色葡萄球菌是最常见的病原体；铜绿假单胞菌也存在早期感染/定植情况。这些信息将有助于改善巴伊亚囊性纤维化参考中心患者的治疗措施。
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