Department of Nutrition and Metabolism, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Am J Clin Nutr. 2012 Jun;95(6):1357-64. doi: 10.3945/ajcn.111.031070. Epub 2012 May 2.
Currently, there is a lack of clarity in the literature as to whether there is a definitive difference between the effects of vitamins D2 and D3 in the raising of serum 25-hydroxyvitamin D [25(OH)D].
The objective of this article was to report a systematic review and meta-analysis of randomized controlled trials (RCTs) that have directly compared the effects of vitamin D2 and vitamin D3 on serum 25(OH)D concentrations in humans.
The ISI Web of Knowledge (January 1966 to July 2011) database was searched electronically for all relevant studies in adults that directly compared vitamin D3 with vitamin D2. The Cochrane Clinical Trials Registry, International Standard Randomized Controlled Trials Number register, and clinicaltrials.gov were also searched for any unpublished trials.
A meta-analysis of RCTs indicated that supplementation with vitamin D3 had a significant and positive effect in the raising of serum 25(OH)D concentrations compared with the effect of vitamin D2 (P = 0.001). When the frequency of dosage administration was compared, there was a significant response for vitamin D3 when given as a bolus dose (P = 0.0002) compared with administration of vitamin D2, but the effect was lost with daily supplementation.
This meta-analysis indicates that vitamin D3 is more efficacious at raising serum 25(OH)D concentrations than is vitamin D2, and thus vitamin D3) could potentially become the preferred choice for supplementation. However, additional research is required to examine the metabolic pathways involved in oral and intramuscular administration of vitamin D and the effects across age, sex, and ethnicity, which this review was unable to verify.
目前，关于维生素 D2 和 D3 在提高血清 25-羟维生素 D [25(OH)D] 方面的作用是否存在明确差异，文献中尚不清楚。
本文旨在报告一项系统评价和荟萃分析，比较了直接比较维生素 D2 和维生素 D3 对人体血清 25(OH)D 浓度影响的随机对照试验 (RCT)。
通过电子方式在 ISI Web of Knowledge（1966 年 1 月至 2011 年 7 月）数据库中搜索了所有关于成人的直接比较维生素 D3 与维生素 D2 的相关研究。还在 Cochrane 临床试验注册中心、国际标准随机对照试验编号登记处和 clinicaltrials.gov 上搜索了任何未发表的试验。
RCT 的荟萃分析表明，与维生素 D2 相比，维生素 D3 补充剂在提高血清 25(OH)D 浓度方面具有显著的积极影响（P = 0.001）。当比较剂量给药频率时，与给予维生素 D2 相比，大剂量给予维生素 D3 时会产生显著的反应（P = 0.0002），但每日补充时效果会消失。
这项荟萃分析表明，维生素 D3 在提高血清 25(OH)D 浓度方面比维生素 D2 更有效，因此维生素 D3 可能成为补充的首选。然而，需要进一步研究口服和肌肉内给予维生素 D 的代谢途径以及年龄、性别和种族的影响，这是本综述无法验证的。
