Asuzu I U, Shetty S N, Anika S M
Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka.
J Ethnopharmacol. 1990 Sep;30(2):135-43. doi: 10.1016/0378-8741(90)90002-b.
Crystals from Croton penduliflorus seeds (CPC) were administered at weekly intervals in two doses (7 mg/kg and 21 mg/kg) by gastric intubation to mice over 12 weeks. CPC induced purgation in the treated mice, with the higher dose having a more profound effect. Mice treated with CPC developed skin lesions with swollen scrotums. There were significant changes in the PCV, Hb and plasma proteins of treated mice. Gangrene of the tail with subsequent sloughing was observed, particularly in the low dose group. Mice in the low dose group also experienced retarded growth. A significant clinical finding in the treated mice was abortion during late pregnancy and 100% fetal mortality. It was concluded that, apart from its purgative effect, CPC can cause toxic effects in chronic administration. Use in pregnant women should be discouraged.
对小鼠进行为期12周的实验，每周通过胃管给其灌胃两次巴豆（Croton penduliflorus）种子晶体（CPC），剂量分别为7毫克/千克和21毫克/千克。CPC使受试小鼠出现腹泻，高剂量组的效果更显著。用CPC处理的小鼠出现皮肤损伤，阴囊肿胀。受试小鼠的红细胞压积、血红蛋白和血浆蛋白有显著变化。观察到小鼠尾巴坏疽并随后脱落，尤其是低剂量组。低剂量组的小鼠还出现生长迟缓。受试小鼠的一个显著临床发现是妊娠后期流产，胎儿死亡率达100%。得出的结论是，除了泻下作用外，长期给药CPC会产生毒性作用。不建议孕妇使用。
