局部应用干扰素α-2B作为结膜上皮内瘤临床病例的首个治疗选择。
Topical interferon alpha-2B topic as the first therapeutic option in a clinical case of conjunctival intraepithelial neoplasia.
作者信息
Pagán Carrasco S, Arranz Maestro D
机构信息
Servicio Extremeño de Salud, Unidad de Córnea y Superficie Anterior, Hospital Nuestra Señora de la Montaña , Cáceres, España.
Servicio Extremeño de Salud, Unidad de Córnea y Superficie Anterior, Hospital Nuestra Señora de la Montaña , Cáceres, España.
出版信息
Arch Soc Esp Oftalmol. 2017 Sep;92(9):442-446. doi: 10.1016/j.oftal.2017.01.013. Epub 2017 Mar 11.
INTRODUCTION
Conjunctival intraepithelial neoplasia is a pre-malignant lesion of the ocular surface. It can be treated with topical interferon alpha-2b (INF α-2b) as first choice.
CLINICAL CASE
A 71-year-old man referred for corneal-conjunctival, gelatinous lesion in the left eye (LE) with an area of almost 270°. The clinical diagnosis was compatible with a corneal-conjunctival intraepithelial neoplasia. Topical treatment was started with INF α-2b at a dose of one million international units (IU)/ml, 4 times/day for 4 months, with remission being achieved.
CONCLUSION
The isolated use of topical INF α-2b is an effective treatment as a first option in the case of corneal-conjunctival intraepithelial neoplasia, positioning itself as a form of effective and safe treatment compared to other therapeutic options. Surgical excision and use of other chemotherapy agents could lead to severe limbic deficits and other side effects.
引言
结膜上皮内瘤变是眼表的一种癌前病变。首选局部应用干扰素α-2b（INFα-2b）进行治疗。
临床病例
一名71岁男性因左眼（LE）角膜结膜处出现面积近270°的凝胶状病变前来就诊。临床诊断为角膜结膜上皮内瘤变。开始局部应用剂量为100万国际单位（IU）/毫升的INFα-2b进行治疗，每天4次，持续4个月，病情得到缓解。
结论
对于角膜结膜上皮内瘤变，单独局部应用INFα-2b作为首选治疗方法是有效的，与其他治疗选择相比，它是一种有效且安全的治疗方式。手术切除和使用其他化疗药物可能会导致严重的角膜缘缺损及其他副作用。
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