手性诱导：氮杂肽中环外双键顺反异构的实验证据。
Induction of chirality: experimental evidence of atropisomerism in azapeptides.
机构信息
Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.
出版信息
Chem Commun (Camb). 2012 Jun 11;48(46):5772-4. doi: 10.1039/c2cc31161e. Epub 2012 May 2.
PMID:22552375
Abstract
Methylation of the peptide bond in model azadipeptides leads to the E configuration and hence to atropisomerism due to a restricted rotation around the N-N axis.
摘要
在模型印苦肽中，肽键的甲基化导致 E 构型，从而由于 N-N 轴的限制旋转而导致构象异构。
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