Department of Plastic and Reconstructive Surgery, Zhejiang Provincial People's Hospital, #158 Shangtang Road, Hangzhou, 310014, People's Republic of China.
Aesthetic Plast Surg. 2012 Aug;36(4):964-70. doi: 10.1007/s00266-012-9899-9. Epub 2012 May 3.
Melasma is a common pigmentary disorder among Asian women. The available therapies such as bleaching agents, chemical peeling, laser, and intense pulsed light are not satisfactory or safe. In the search to find a new treatment therapy for melasma, oral administration of tranexamic acid (TA) was studied clinically in Chinese patients.
The study enrolled 74 patients. Tranexamic acid tablets were prescribed at a dosage of 250 mg twice daily for a therapeutic period of 6 months. All the patients were followed up for more than 6 months after the treatment. The effects of treatment were evaluated by two physicians independently and by the patient based on improvement of pigmentation and reduction in melasma size. These were graded into four levels: excellent, good, fair, and poor.
After 6 months of treatment, the effects were graded as follows: excellent (10.8%, 8/74), good (54%, 40/74), fair (31.1%, 23/74), and poor (4.1%, 3/74). Side effects of TA such as gastrointestinal discomfort (5.4%) and hypomenorrhea (8.1%) were observed, but no severe complications were found. The recurrence of melasma was observed in seven cases (9.5%).
Oral administration of TA is an effective and safe therapy for the treatment of melasma.
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黄褐斑是亚洲女性中常见的色素沉着性疾病。现有的治疗方法，如漂白剂、化学换肤、激光和强脉冲光等，并不令人满意或安全。为了寻找治疗黄褐斑的新方法，我们对中国患者进行了氨甲环酸（TA）口服治疗的临床研究。
该研究纳入了 74 名患者。TA 片的剂量为 250mg，每日两次，治疗期为 6 个月。所有患者在治疗后均随访 6 个月以上。两名医生和患者均根据色素沉着改善和黄褐斑面积缩小对治疗效果进行独立评估和分级：优、良、中、差。
治疗 6 个月后，疗效分级如下：优（10.8%，8/74）、良（54%，40/74）、中（31.1%，23/74）、差（4.1%，3/74）。TA 的副作用如胃肠道不适（5.4%）和月经过少（8.1%），但未发现严重并发症。7 例（9.5%）患者出现黄褐斑复发。
口服 TA 是治疗黄褐斑的一种有效且安全的方法。
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