Pirenne J, D'Silva M, Hamoir E, Lardinois F, Fridman V, Mahieu P, Honore P, Meurisse M, Jacquet N
Department of Surgery, University of Liege, Belgium.
Microsurgery. 1990;11(4):303-8. doi: 10.1002/micr.1920110413.
The influence of the length and origin of a small bowel graft on graft versus host disease (GVHD) was studied in 33 (Lewis x brown Norway) F1 hybrids transplanted with different types of Lewis small bowel grafts. Recipients of an entire small bowel graft (N = 9), a jejunal graft (N = 6), or an ileal graft (N = 6) displayed a similar acute lethal GVHD, with 100% mortality rate and equivalent survival time (15 +/- 0.7, 16.8 +/- 0.9, and 16 +/- 0.6 days, respectively) (P greater than 0.01). On the other hand, 80% of the recipients of a segmental jejunal graft (N = 10) recovered from a transitory form of GVHD and regained weight similarly to the isografted rats (N = 4). It was concluded that the entire small bowel, jejunum, and ileum can provoke an equivalent GVHD after transplantation, whereas a segment of jejunum decreases the intensity of GVHD, probably by reducing the amount of transplanted lymphoid tissue.
在33只接受不同类型Lewis小肠移植的（Lewis×棕色挪威大鼠）F1杂交种中，研究了小肠移植物的长度和来源对移植物抗宿主病（GVHD）的影响。接受全小肠移植（N = 9）、空肠移植（N = 6）或回肠移植（N = 6）的受体表现出相似的急性致死性GVHD，死亡率均为100%，生存时间相当（分别为15±0.7天、16.8±0.9天和16±0.6天）（P＞0.01）。另一方面，80%接受节段性空肠移植的受体（N = 10）从短暂性GVHD中恢复，体重恢复情况与同基因移植大鼠（N = 4）相似。得出的结论是，全小肠、空肠和回肠在移植后可引发相当的GVHD，而一段空肠可能通过减少移植淋巴组织的数量来降低GVHD的强度。
