Department of Pathology, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
World J Gastroenterol. 2012 Apr 21;18(15):1793-9. doi: 10.3748/wjg.v18.i15.1793.
To correlate cyclooxygenase-2 (COX-2) expression profile with clinical and pathological variables to assess their prognostic/predictive value in colorectal carcinoma (CRC).
Archival tumor samples were analyzed using immunohistochemistry for COX-2 expression in 94 patients with CRC. Patients were diagnosed and treated at the Departments of Surgery and Oncology, King Abdulaziz University Hospital, Saudi Arabia.
Fifty-six percent of the tumors showed positive cytoplasmic COX-2 expression, whereas 44% of cases were completely COX-2-negative. There were no significant correlations between COX-2 expression and sex, age, grade or tumor location. However, COX-2 expression revealed a significant correlation with tumor stage (P = 0.01) and distant metastasis (P = 0.02), and a borderline association with lymph node involvement (P = 0.07). Tumors with high COX-2 expression showed a higher recurrence rate than tumors with no expression (P < 0.009). In univariate Kaplan-Meier survival analysis, there was a significant (P = 0.026) difference in disease-free survival between COX-2-positive and negative tumors in favor of the latter. COX-2 expression did not significantly predict disease-specific survival, which was much shorter for COX-2-positive tumors. In multivariate (COX) models, COX-2 did not appear among the independent predictors of disease-free survival or disease-specific survival.
COX-2 expression seems to provide useful prognostic information in CRC, while predicting the patients at high risk for recurrent disease.
通过分析环氧化酶-2（COX-2）的表达谱与临床和病理变量之间的相关性，评估其在结直肠癌（CRC）中的预后/预测价值。
采用免疫组织化学方法对 94 例 CRC 患者的肿瘤样本进行 COX-2 表达分析。这些患者在沙特阿拉伯阿卜杜勒阿齐兹国王大学医院的外科和肿瘤科被诊断和治疗。
56%的肿瘤显示细胞质 COX-2 表达阳性，而 44%的病例完全 COX-2 阴性。COX-2 表达与性别、年龄、分级或肿瘤位置之间无显著相关性。然而，COX-2 表达与肿瘤分期（P = 0.01）和远处转移（P = 0.02）显著相关，与淋巴结受累（P = 0.07）呈边缘相关。COX-2 高表达的肿瘤比无表达的肿瘤复发率更高（P < 0.009）。在单变量 Kaplan-Meier 生存分析中，COX-2 阳性和阴性肿瘤在无病生存率方面存在显著差异（P = 0.026），后者更好。COX-2 表达并不能显著预测疾病特异性生存率，COX-2 阳性肿瘤的生存率更短。在多变量（COX）模型中，COX-2 并未成为无病生存率或疾病特异性生存率的独立预测因素。
COX-2 表达似乎为 CRC 提供了有用的预后信息，同时预测了那些患有复发性疾病风险较高的患者。
