全视网膜激光光凝对增殖性糖尿病视网膜病变患者血浆血管内皮生长因子、内皮素-1及一氧化氮的影响
Effect of pan-retinal laser photocoagulation on plasma VEGF, endothelin-1 and nitric oxide in PDR.
作者信息
Mohamed Tarek Ahmed, Mohamed Sahar El-Deek
机构信息
Department of Ophthalmology, Assiut University Hospitals, Assiut University, Assiut, Egypt.
出版信息
Int J Ophthalmol. 2010;3(1):19-22. doi: 10.3980/j.issn.2222-3959.2010.01.05. Epub 2010 Mar 18.
Abstract
AIM
To study plasma levels of vascular endothelial growth factor (VEGF), endothelin-1(ET-1) and nitric oxide (NO) in patients with proliferative diabetic retinopathy (PDR) before and after pan-retinal photocoagulation (PRP).
METHODS
Forty patients (23 females and 17 males, mean age 48.5±12.2 years) with PDR without previous PRP therapy were studied. Blood samples were obtained before and 3 months after the last PRP session. Baseline (prelaser) plasma levels of VEGF, ET-1 and NO were compared with their levels in 30 healthy age- and sex- matched controls and also with plasma levels 3 months post-PRP.
RESULTS
Patients with PDR had significantly raised plasma VEGF (375±89ng/L), ET-1(20±5ng/L) and NO (135±53µmol/L) when compared with healthy control group (P<0.01). After PRP, there was a significant reduction in plasma VEGF (179±66ng/L), ET-1 (11±5ng/L) and NO (91±49µmol/L) levels at 3 months' follow-up but still significantly higher than healthy controls.
CONCLUSION
Patients with PDR demonstrate elevated VEGF, ET-1 and NO, which decrease after successful laser treatment.
摘要
目的
研究增殖性糖尿病视网膜病变（PDR）患者在全视网膜光凝（PRP）治疗前后血管内皮生长因子（VEGF）、内皮素-1（ET-1）和一氧化氮（NO）的血浆水平。
方法
对40例未经PRP治疗的PDR患者（23例女性，17例男性，平均年龄48.5±12.2岁）进行研究。在最后一次PRP治疗前及治疗后3个月采集血样。将VEGF、ET-1和NO的基线（激光治疗前）血浆水平与30例年龄和性别匹配的健康对照者的水平进行比较，并与PRP治疗后3个月的血浆水平进行比较。
结果
与健康对照组相比，PDR患者的血浆VEGF（375±89ng/L）、ET-1（20±5ng/L）和NO（135±53µmol/L）显著升高（P<0.01）。PRP治疗后，随访3个月时血浆VEGF（179±66ng/L）、ET-1（11±5ng/L）和NO（91±49µmol/L）水平显著降低，但仍显著高于健康对照组。
结论
PDR患者的VEGF、ET-1和NO水平升高，成功的激光治疗后这些水平降低。
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