Ismaeel Omar M S, Jaafar Hasnan, Ibrahim Mohtar
Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia.
Int J Ophthalmol. 2010;3(3):245-8. doi: 10.3980/j.issn.2222-3959.2010.03.15. Epub 2010 Sep 18.
To detect the presence of 8-hydroxydeoxyguanosine enzyme (8-OHdG) in recurrent pterygium and its role on recurrence.
Ninty-two samples were collected of which 55 from primary pterygium, 12 from recurrent and 25 from normal conjunctiva. A cross sectional study was embarked to detect the presence of the 8-OHdG enzyme in primary, recurrent pterygium and the normal conjunctival tissue by immunohistochemistry test.
THE IMMUNOHISTOCHEMISTRY TEST SHOWED POSITIVE RESULTS: 35 in primary, 2 in recurrent pterygia and 4 in normal conjunctiva, respectively. Significant association between primary pterygium and 8-OHdG enzyme (63.6% of samples are positive) and no significant relation was detected with recurrent pterygium (16.7% of samples are positive).
8-OHdG enzyme is associated with primary pterygium. It is also present in normal conjunctival tissue. For the first time it is detected in recurrent pterygia. This may raise question whether 8-OHdG enzyme has a role in recurrence of pterygium.
检测复发性翼状胬肉中8-羟基脱氧鸟苷酶（8-OHdG）的存在及其在复发中的作用。
收集92份样本，其中55份来自原发性翼状胬肉，12份来自复发性翼状胬肉，25份来自正常结膜。开展一项横断面研究，通过免疫组织化学检测在原发性、复发性翼状胬肉及正常结膜组织中检测8-OHdG酶的存在情况。
免疫组织化学检测显示阳性结果：原发性翼状胬肉中35份呈阳性，复发性翼状胬肉中2份呈阳性，正常结膜中4份呈阳性。原发性翼状胬肉与8-OHdG酶之间存在显著关联（63.6%的样本呈阳性），而复发性翼状胬肉未检测到显著关联（16.7%的样本呈阳性）。
8-OHdG酶与原发性翼状胬肉有关。它也存在于正常结膜组织中。首次在复发性翼状胬肉中检测到该酶。这可能会引发关于8-OHdG酶是否在翼状胬肉复发中起作用的疑问。
