Liu Lin, Li Yong-Ping, Zhang Bo, Zhang Wen-Xin
Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, Guangdong Province, China.
Int J Ophthalmol. 2012;5(1):23-7. doi: 10.3980/j.issn.2222-3959.2012.01.05. Epub 2012 Feb 18.
To investigate auto-cortex of crystalline lens induced iris neovascularization (INV).
Thirty-six eyes of 36 guinea-pigs were included and divided into three groups randomly in this cohort study. Group A: the right lens nucleus was extracted and the remaining cortical lens material was aspirated thoroughly. Group B: the lens was removed and 30µL precipitated lens cortex was injected into the anterior chamber again. Group C: aspirated the lens cortex of the left eyes and inject them into the right anterior chambers about 10µL. Clinical changes were followed by slit-lamp examination and photograph. The eye balls were enucleated at the day of 2, 4, 7, 11, 13, 17 after operation. HE was used to detect the pathological changes.
INV had not been observed until the end of empirical study. The stromal layer contained thick wall vessels, without expansion. Group B: All eyes developed INV. Postoperative (po) 7 days; the eyes developed intense and extensive INV. The vessels of iris expanded remarkably and neovascularization was observed erupting from it's lateral wall and stretching towards the anterior surface. Po11 days, INV regressed gradually after lens cortex had been absorbed. Group C: Po four (4) days, new blood vessels liking red line were presented on the anterior surface of the iris and they were not obvious.
Anterior chamber inside lens coriaceous can induce iris new blood vessels.
研究晶状体自身皮质诱导的虹膜新生血管形成（INV）。
本队列研究纳入36只豚鼠的36只眼，并随机分为三组。A组：摘除右眼晶状体核，并彻底吸出剩余的晶状体皮质物质。B组：摘除晶状体，然后将30μL沉淀的晶状体皮质再次注入前房。C组：吸出左眼晶状体皮质，并将约10μL注入右眼前房。通过裂隙灯检查和拍照观察临床变化。术后第2、4、7、11、13、17天摘除眼球。采用苏木精-伊红染色（HE）检测病理变化。
A组：直至实验研究结束均未观察到INV。基质层含有厚壁血管，无扩张。B组：所有眼均发生INV。术后7天，眼内出现强烈且广泛的INV。虹膜血管明显扩张，观察到新生血管从其侧壁喷出并向前表面延伸。术后11天，晶状体皮质吸收后INV逐渐消退。C组：术后4天，虹膜前表面出现呈红线状的新生血管，且不明显。
前房内的晶状体皮质可诱导虹膜新生血管形成。
