Shabo A L, Maxwell D S, Shintaku P, Kreiger A E, Straatsma B R
Invest Ophthalmol Vis Sci. 1977 Apr;16(4):343-52.
We have developed a primate model of rubeosis iridis in monkeys systemically sensitized to crystalline beef insulin. After intravitreal insulin injection, the dose-related immunogenic inflammation includes cells, flare, fibrin, and blood in the anterior chamber. With more severe inflammation, posterior synechiae, iris bombé, and cataracts occur. Of particular importance, new blood vessels develop within the stroma and on the anterior surface of the iris. Following injection of small amounts of insulin, the anterior surface vessels may regress over time, and the iris regains its normal appearance and coloration. However, the new stromal vessels persist and are cuffed by inflammatory cells including plasma cells. After injection of large amounts of insulin, more extensive structural alterations develop as noted above in conjunction with persistent iris anterior surface and stromal neovascularization. The relationship of rubeosis iridis to clinical inflammatory syndromes and to previous laboratory studies is discussed. Stromal neovascularization was a consistent finding in this experimental model even when anterior surface vessels regressed. On the basis of these experimental data and a review of publications describing human pathology, we believe that a broadening of the classic definition of rubeosis iridis is waranted to include a recognition of the stromal component of the clinical and pathologic findings.
我们已经建立了一种猴虹膜新生血管的灵长类动物模型，该模型通过对结晶牛胰岛素进行全身致敏而获得。玻璃体内注射胰岛素后，剂量相关的免疫原性炎症包括前房内的细胞、闪光、纤维蛋白和血液。随着炎症加重，会出现后粘连、虹膜膨隆和白内障。特别重要的是，虹膜基质内和前表面会形成新血管。注射少量胰岛素后，前表面血管可能会随时间消退，虹膜恢复其正常外观和颜色。然而，新的基质血管会持续存在，并被包括浆细胞在内的炎症细胞包绕。注射大量胰岛素后，会出现如上文所述的更广泛的结构改变，同时伴有虹膜前表面和基质新生血管持续存在。本文讨论了虹膜新生血管与临床炎症综合征以及既往实验室研究的关系。即使前表面血管消退，基质新生血管在该实验模型中仍是一个持续存在的发现。基于这些实验数据以及对描述人类病理学的出版物的综述，我们认为有必要扩大虹膜新生血管的经典定义，以纳入对临床和病理结果中基质成分的认识。
