Department of Chronic Communicable Disease, Nanjing Municipal Center for Disease Control and Prevention, Nanjing, China.
Respirology. 2012 Jul;17(5):847-53. doi: 10.1111/j.1440-1843.2012.02185.x.
Dendritic cell-specific intracellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN), encoded by the CD209 gene, is a major Mycobacterium tuberculosis receptor on human dendritic cells. The potentially functional -336A/G polymorphism in the CD209 promoter region has been associated with susceptibility to tuberculosis (TB), but the results have been inconclusive. We performed a meta-analysis to clarify the relationship between the CD209-336A/G variant and the risk of TB.
Ten studies involving a total of 2598 TB patients and 2614 control subjects were systematically reviewed, and the data were quantitatively synthesized by meta-analysis. The Q-test was applied to assess the heterogeneity of associations among the studies, and Egger's regression test was used to assess potential publication bias.
No significant association was identified between the CD209-336A/G polymorphism and risk of TB (G allele vs A allele: odds ratio (OR) 1.02, 95% confidence interval (CI) 0.90-1.15). Moreover, no significant association was observed in populations of African ethnicity (OR 1.01, 95% CI 0.87-1.17) or among individuals who were negative for the human immunodeficiency virus (OR 0.98, 95% CI 0.84-1.15).
This meta-analysis has indicated that the CD209-336A/G polymorphism may not contribute to susceptibility to TB.
树突状细胞特异性细胞间黏附分子-3 捕获非整合素（DC-SIGN），由 CD209 基因编码，是人类树突状细胞上主要的结核分枝杆菌受体。CD209 启动子区域的潜在功能性-336A/G 多态性与结核病（TB）易感性相关，但结果尚无定论。我们进行了一项荟萃分析，以阐明 CD209-336A/G 变异与 TB 风险之间的关系。
系统性地回顾了 10 项研究，共涉及 2598 例 TB 患者和 2614 例对照，采用荟萃分析对数据进行定量综合。采用 Q 检验评估研究之间关联的异质性，采用 Egger 回归检验评估潜在的发表偏倚。
CD209-336A/G 多态性与 TB 风险之间无显著关联（G 等位基因与 A 等位基因：比值比（OR）1.02，95%置信区间（CI）0.90-1.15）。此外，在非裔人群（OR 1.01，95%CI 0.87-1.17）或人类免疫缺陷病毒阴性个体（OR 0.98，95%CI 0.84-1.15）中也未观察到显著关联。
本荟萃分析表明，CD209-336A/G 多态性可能与 TB 易感性无关。
