Department of Gerontology, Geriatry and Metabolic Diseases, UOC of General and Geriatric Surgery, School of Medicine, Second University of the Study of Naples, Naples, Italy.
World J Surg Oncol. 2012 May 3;10:73. doi: 10.1186/1477-7819-10-73.
The finding of thyroid nodules is a very common occurrence in routine clinical practice. Approximately 5% to 7% of the entire population have thyroid nodules. Vascular lesions are one of the most controversial issues in thyroid pathology. These include benign lesions such as hemangiomas and, rarely, malignant tumors such as angiosarcomas or undifferentiated angiosarcomatoid carcinomas. In particular, angiosarcoma of the thyroid gland is a rare, highly aggressive malignant vascular tumor and in Italy the greatest geographical incidence of this lesion is witnessed near the Alps. Here, a case of thyroid angiosarcoma in a 71-year-old man with a history of goiter for about 20 years is described. The unusual localization of this lesion, the difficulties in reaching a definitive diagnosis for this particular histological type of primary tumor and a history of long-standing multinodular goiter in thyroid of an older man from outside the Alpine region prompted us to report this case of thyroid angiosarcoma mainly to discuss surgical, histopathological and immunohistochemical features.
甲状腺结节的发现是临床实践中非常常见的现象。大约 5%至 7%的整个人群有甲状腺结节。血管病变是甲状腺病理学中最具争议的问题之一。这些包括良性病变，如血管瘤，以及罕见的恶性肿瘤，如血管肉瘤或未分化的血管肉瘤样癌。特别是甲状腺血管肉瘤是一种罕见的、高度侵袭性的恶性血管肿瘤，在意大利，这种病变的最大地理发病率在阿尔卑斯山附近。在这里，描述了一例 71 岁男性的甲状腺血管肉瘤病例，该患者有大约 20 年的甲状腺肿病史。这种病变的不常见位置、对于这种特定组织学类型的原发性肿瘤进行明确诊断的困难以及来自阿尔卑斯山以外地区的老年男性长期多发性甲状腺肿的病史促使我们报告这例甲状腺血管肉瘤病例，主要是为了讨论手术、组织病理学和免疫组织化学特征。
