Lamovec J, Zidar A, Zidanik B
Department of Pathology, Institute of Oncology, Ljubjana, Slovenia.
Arch Pathol Lab Med. 1994 Jun;118(6):642-6.
We present two cases of epithelioid angiosarcoma of the thyroid gland from two patients in Slovenia. In both cases, the tumor appeared as a dominant nodule in a multinodular goiter. Histological appearance of the tumor was similar in both cases and characterized by large epithelioid tumor cells with numerous intracytoplasmic lumina, large nuclei, and very prominent nucleoli. Such cells formed vascular structures as well. Neoplastic cells were positive for factor VIII-associated antigen in both cases. Reaction to Ulex europaeus lectin was positive in one case, and characteristic ultrastructural features were seen in another case. In both cases, some neoplastic cells also showed keratin positivity. Angiosarcoma is a rare but definite possibility in a differential diagnosis of anaplastic thyroid tumors in Slovenia.
我们展示了来自斯洛文尼亚两名患者的两例甲状腺上皮样血管肉瘤病例。在这两例病例中，肿瘤均表现为多结节性甲状腺肿中的一个优势结节。两例病例中肿瘤的组织学表现相似，其特征为具有大量胞质内管腔的大上皮样肿瘤细胞、大细胞核以及非常明显的核仁。这些细胞也形成了血管结构。两例病例中的肿瘤细胞对因子VIII相关抗原均呈阳性反应。一例病例对荆豆凝集素呈阳性反应，另一例病例可见特征性超微结构特征。在两例病例中，一些肿瘤细胞也显示角蛋白阳性。在斯洛文尼亚，血管肉瘤在间变性甲状腺肿瘤的鉴别诊断中是一种罕见但确切存在的可能性。
