Ministry of Health, Private Provincial Administration of Istanbul, Oral and Dental Diseases Hospital, Clinic of Oral and Maxillofacial Surgery, Istanbul, Turkey.
J Oral Pathol Med. 2012 Oct;41(9):689-96. doi: 10.1111/j.1600-0714.2012.01160.x. Epub 2012 May 3.
The aim of this study was to investigate the roles of Matrix Metalloproteinases (MMP)-2, Metalloproteinases-7, Metalloproteinases-10 and Tissue Inhibitors of Metalloproteinase-1 (TIMP-1) in the pathogenesis of oral lichen planus (OLP) disease in same tissue samples.
Thirty-nine individuals [29 patients with OLP (74%) and 10 healthy control subjects (25%)] were included in our study. The mean age was 48 ± 14.39 with a range of 20-75.
MMP-2 and MMP-7 expression was significantly different in the patient and control groups in the epithelium and the connective tissue (P<0. 05). The ratio of MMP-2/TIMP-1 and MMP-7/TIMP-1 were higher in patient with OLP group than control group.
Along with the exposure of the role of MMPs activity on diseases characterized by the tissue destruction, several studies were conducted on the pharmacological control of MMPs activity. However, understanding of the biological functions of MMPs is very important for the development and implementation of MMP inhibitors in the treatment of diseases. According to the results of this study, we suggest that MMP-2, MMP-7, and TIMP-1 may be involved in the formation of OLP lesions. Further studies on MMPs may be useful for understanding and treating the diseases such as OLP.
本研究旨在探讨基质金属蛋白酶（MMP）-2、MMP-7、MMP-10 和组织金属蛋白酶抑制剂-1（TIMP-1）在口腔扁平苔藓（OLP）病变中的作用。
本研究共纳入 39 名个体[29 名 OLP 患者（74%）和 10 名健康对照者（25%）]。平均年龄为 48 ± 14.39 岁，范围为 20-75 岁。
MMP-2 和 MMP-7 在患者组和对照组的上皮和结缔组织中的表达存在显著差异（P<0.05）。OLP 组 MMP-2/TIMP-1 和 MMP-7/TIMP-1 比值高于对照组。
随着 MMP 活性在以组织破坏为特征的疾病中的作用的揭示，已经进行了几项关于 MMP 活性的药理学控制的研究。然而，了解 MMP 的生物学功能对于 MMP 抑制剂在治疗疾病中的开发和应用非常重要。根据本研究的结果，我们认为 MMP-2、MMP-7 和 TIMP-1 可能参与了 OLP 病变的形成。对 MMP 的进一步研究可能有助于理解和治疗 OLP 等疾病。
