Zhu Xin, Wei Daming, Okazaki Osamu
Biomedical Information Technology Lab, the University of Aizu, Tsuruga, Ikki-machi, Aizu-Wakamatsu, Fukushima, Japan.
Pacing Clin Electrophysiol. 2012 Jun;35(6):718-29. doi: 10.1111/j.1540-8159.2012.03379.x. Epub 2012 May 3.
Computer simulation is an important method for the basic researches of cardiac electrophysiology to prove the mechanisms and hypotheses of cardiac arrhythmias by reproducing body surface electrocardiograms. In this research, we extend the researches of heart models to the computer simulation of clinical electrophysiological study (EPS) as a clinical application of heart models.
Through setting the standard EPS pacing protocols, including extrastimuli and incremental pacing in the heart models, we simulated the corresponding excitation propagations in the heart and the intracardiac electrograms that would be measured with catheter electrodes.
Examples of complicated cases observed during EPS are reproduced in this research, including the induction of a Wenckebach pattern, the induction and termination of supraventricular tachycardia due to the reentry loop of antidromic atrioventricular reentrant tachycardia for the Wolff-Parkinson-White (WPW) syndrome (Type A), and the localization of an accessory pathway for the WPW syndrome (Type A).
This study demonstrates an application of whole-heart modeling and computer simulation to clinical EPS.
计算机模拟是心脏电生理学基础研究的重要方法，通过重现体表心电图来证明心律失常的机制和假说。在本研究中，我们将心脏模型的研究扩展到临床电生理研究（EPS）的计算机模拟，作为心脏模型的临床应用。
通过在心脏模型中设置标准的EPS起搏方案，包括额外刺激和递增起搏，我们模拟了心脏中相应的兴奋传播以及用导管电极测量的心内心电图。
本研究重现了EPS期间观察到的复杂病例实例，包括文氏现象的诱发、由于 Wolff-Parkinson-White（WPW）综合征（A型）的逆向房室折返性心动过速折返环导致的室上性心动过速的诱发和终止，以及WPW综合征（A型）附加通路的定位。
本研究展示了全心建模和计算机模拟在临床EPS中的应用。
