3M Company, Medical Department, St. Paul, Minnesota, United States.
Environ Sci Technol. 2012 Jun 5;46(11):6330-8. doi: 10.1021/es300604p. Epub 2012 May 11.
Eleven perfluorinated alkyl acids (PFAAs) were analyzed in plasma from a total of 600 American Red Cross adult blood donors from six locations in 2010. The samples were extracted by protein precipitation and quantified by using liquid chromatography tandem mass spectrometry (HPLC/MS/MS). The anions of the three perfluorosulfonic acids measured were perfluorobutane sulfonate (PFBS), perfluorohexane sulfonate (PFHxS), and perfluorooctane sulfonate (PFOS). The anions of the eight perfluorocarboxylic acids were perfluoropentanoate (PFPeA), perfluorohexanoate (PFHxA), perfluoroheptanoate (PFHpA), perfluorooctanoate (PFOA), perfluorononanoate (PFNA), perfluorodecanoate (PFDA), perfluoroundecanoate (PFUnA), and perfluorododecanoate (PFDoA). Findings were compared to results from different donor samples analyzed at the same locations collected in 2000-2001 (N = 645 serum samples) and 2006 (N = 600 plasma samples). Most measurements in 2010 were less than the lower limit of quantitation for PFBS, PFPeA, PFHxA, and PFDoA. For the remaining analytes, the geometric mean concentrations (ng/mL) in 2000-2001, 2006, and 2010 were, respectively, PFHxS: (2.25, 1.52, 1.34); PFOS (34.9, 14.5, 8.3); PFHpA (0.13, 0.09, 0.05); PFOA (4.70, 3.44, 2.44); PFNA (0.57, 0.97, 0.83); PFDA (0.16, 0.34, 0.27), and PFUnA (0.10, 0.18, 0.14). The percentage decline (parentheses) in geometric mean concentrations from 2000-2001 to 2010 were PFHxS (40%), PFOS (76%), and PFOA (48%). The decline in PFOS suggested a population halving time of 4.3 years. This estimate is comparable to the geometric mean serum elimination half-life of 4.8 years reported in individuals. This similarity supports the conclusion that the dominant PFOS-related exposures to humans in the United States were greatly mitigated during the phase-out period.
2010 年，从美国红十字会 6 个地点的 600 名成年献血者的血浆中分析了 11 种全氟烷基酸 (PFAAs)。采用蛋白质沉淀法提取样品，并通过液相色谱串联质谱法 (HPLC/MS/MS) 进行定量。所测量的三种全氟磺酸阴离子为全氟丁烷磺酸 (PFBS)、全氟己烷磺酸 (PFHxS) 和全氟辛烷磺酸 (PFOS)。八种全氟羧酸的阴离子为全氟戊酸 (PFPeA)、全氟己酸 (PFHxA)、全氟庚酸 (PFHpA)、全氟辛酸 (PFOA)、全氟壬酸 (PFNA)、全氟癸酸 (PFDA)、全氟十一烷酸 (PFUnA) 和全氟十二烷酸 (PFDoA)。将结果与 2000-2001 年（N=645 份血清样本）和 2006 年（N=600 份血浆样本）同一地点采集的不同供体样本的分析结果进行比较。2010 年的大多数测量值均低于 PFBS、PFPeA、PFHxA 和 PFDoA 的定量下限。对于其余分析物，2000-2001 年、2006 年和 2010 年的几何平均值浓度（ng/mL）分别为：PFHxS（2.25、1.52、1.34）；PFOS（34.9、14.5、8.3）；PFHpA（0.13、0.09、0.05）；PFOA（4.70、3.44、2.44）；PFNA（0.57、0.97、0.83）；PFDA（0.16、0.34、0.27）和 PFUnA（0.10、0.18、0.14）。2000-2001 年至 2010 年几何平均值浓度的百分比下降（括号内）分别为：PFHxS（40%）、PFOS（76%）和 PFOA（48%）。PFOS 的下降表明，人群减半时间为 4.3 年。这一估计与个体报告的 PFOS 血清消除半衰期 4.8 年相当。这种相似性支持这样的结论，即美国人类接触全氟辛烷磺酸的主要来源在淘汰期间得到了极大缓解。
