基于钌（II）配合物的荧光传感器用于检测过氧亚硝酸盐。
Ruthenium(II) complex-based fluorescent sensor for peroxynitrite.
机构信息
Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, The Chinese Academy of Sciences, Beijing 100190, PR China.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2012 Aug;94:340-5. doi: 10.1016/j.saa.2012.03.067. Epub 2012 Mar 30.
We have developed a new ruthenium complex, Ru(bpy)(2)[4-(2,2'-bipyridin-4-yloxy)phenol]Cl(2) (RuL), as a fluorescent sensor to detect peroxynitrite (ONOO(-)). The results showed that the addition of ONOO(-) to the aqueous solution of RuL would result in distinct fluorescence quenching at 600nm. RuL exhibits a good selectivity for ONOO(-) over other reactive oxygen species (ROS) and reactive nitrite species (RNS), and the reaction time is less than 1.5s. The sensing mechanism is proposed as the oxidative O-dealkylation reaction.
我们开发了一种新的钌配合物 Ru(bpy)(2)[4-(2,2'-联吡啶-4-基氧基)苯酚]Cl(2)（RuL），作为一种荧光传感器来检测过氧亚硝酸盐（ONOO(-)）。结果表明，将 ONOO(-)加入 RuL 的水溶液中，会导致在 600nm 处出现明显的荧光猝灭。RuL 对 ONOO(-)表现出良好的选择性，优于其他活性氧物种（ROS）和活性亚硝酸盐物种（RNS），反应时间小于 1.5s。该传感机制被提出为氧化 O-脱烷基反应。
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