一种基于 N-(2-氨基苯基)-5-(二甲基氨基)-1-萘磺酰胺（Ds-DAB）的荧光化学传感器，用于检测过氧亚硝酸盐。
A N-(2-aminophenyl)-5-(dimethylamino)-1-naphthalenesulfonic amide (Ds-DAB) based fluorescent chemosensor for peroxynitrite.
机构信息
Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 300, Taiwan.
出版信息
Org Lett. 2013 Aug 16;15(16):4242-5. doi: 10.1021/ol401932p. Epub 2013 Aug 7.
A dansyl derivative (Ds-DAB) was prepared and used as a fluorescent probe for peroxynitrite (ONOO(-)) detection. The results showed that the addition of peroxynitrite to the aqueous solution of Ds-DAB would result in obvious fluorescence enhancement. This probe is highly specific for peroxynitrite in aqueous solution, avoiding interference from other reactive oxygen species (ROS) and nitrogen species (RNS). The advantages of high selectivity, fast reaction rate, and peroxynitrite bioimaging render Ds-DAB suitable for peroxynitrite detection.
制备了一种丹磺酰基衍生物（Ds-DAB），并将其用作检测过氧亚硝酸盐（ONOO(-)）的荧光探针。结果表明，将过氧亚硝酸盐加入 Ds-DAB 的水溶液中会导致明显的荧光增强。该探针对水溶液中的过氧亚硝酸盐具有高度特异性，可避免其他活性氧（ROS）和氮物种（RNS）的干扰。高选择性、快速反应速率和过氧亚硝酸盐生物成像的优势使得 Ds-DAB 适合用于过氧亚硝酸盐的检测。
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