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基于钌（II）配合物的化学传感器用于小分子生物分子和离子的测定与成像。

Determination and Imaging of Small Biomolecules and Ions Using Ruthenium(II) Complex-Based Chemosensors.

机构信息

Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia.

School of Agriculture and Food Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia.

出版信息

Top Curr Chem (Cham). 2022 Jun 13;380(5):29. doi: 10.1007/s41061-022-00392-8.

DOI:10.1007/s41061-022-00392-8
PMID:35695976
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9192387/
Abstract

Luminescence chemosensors are one of the most useful tools for the determination and imaging of small biomolecules and ions in situ in real time. Based on the unique photo-physical/-chemical properties of ruthenium(II) (Ru(II)) complexes, the development of Ru(II) complex-based chemosensors has attracted increasing attention in recent years, and thus many Ru(II) complexes have been designed and synthesized for the detection of ions and small biomolecules in biological and environmental samples. In this work, we summarize the research advances in the development of Ru(II) complex-based chemosensors for the determination of ions and small biomolecules, including anions, metal ions, reactive biomolecules and amino acids, with a particular focus on binding/reaction-based chemosensors for the investigation of intracellular analytes' evolution through luminescence analysis and imaging. The advances, challenges and future research directions in the development of Ru(II) complex-based chemosensors are also discussed.

摘要

发光化学传感器是用于实时原位测定和成像小分子生物分子和离子的最有用的工具之一。基于钌（II）（Ru（II））配合物的独特光物理/-化学性质，近年来，基于 Ru（II）配合物的化学传感器的开发引起了越来越多的关注，因此设计和合成了许多 Ru（II）配合物用于检测生物和环境样品中的离子和小分子生物分子。在这项工作中，我们总结了开发基于 Ru（II）配合物的化学传感器用于测定离子和小分子生物分子（包括阴离子、金属离子、反应性生物分子和氨基酸）的研究进展，特别关注通过发光分析和成像研究细胞内分析物演变的基于结合/反应的化学传感器。还讨论了基于 Ru（II）配合物的化学传感器的发展中的进展、挑战和未来研究方向。

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