Institut Pasteur, Unité des Interactions Bactéries-Cellules, Département de Biologie Cellulaire et Infection, F-75015 Paris, France.
Trends Cell Biol. 2012 Jun;22(6):283-91. doi: 10.1016/j.tcb.2012.03.006. Epub 2012 May 1.
In order to survive inside the host cell, bacterial pathogens have evolved a variety of mechanisms to avoid or interfere with innate immune defenses. Several reports have shown that bacterial pathogens are targeted by the autophagy pathway, and autophagy has been increasingly recognized as an important defense mechanism to clear intracellular microbes. However, it now appears that some bacterial pathogens have evolved mechanisms to evade autophagic recognition or even co-opt the autophagy machinery for their own benefit as a replicative niche. A complete understanding of bacterial autophagy in vivo shall be critical to exploit autophagy and its therapeutic potential.
为了在宿主细胞内生存，细菌病原体进化出了多种机制来避免或干扰先天免疫防御。有几项研究表明，细菌病原体是自噬途径的靶标，自噬已越来越被认为是清除细胞内微生物的重要防御机制。然而，现在似乎一些细菌病原体已经进化出了逃避自噬识别的机制，甚至将自噬机制篡夺为自己的复制栖所。对体内细菌自噬的全面理解对于开发自噬及其治疗潜力至关重要。
