慢性肾脏病与认知障碍：系统评价与荟萃分析。

Chronic kidney disease and cognitive impairment: a systematic review and meta-analysis.

机构信息

Department of Psychiatry and Psychotherapy, Technische Universität München, München, Germany. thorleif.etgen @ klinikum-traunstein.de

出版信息

Am J Nephrol. 2012;35(5):474-82. doi: 10.1159/000338135. Epub 2012 May 3.

DOI:10.1159/000338135

PMID:22555151

Abstract

BACKGROUND

Chronic kidney disease (CKD) has emerged as a possible new risk factor of cognitive impairment and dementia, but results of studies remain conflicting.

METHODS

A systematic literature research of electronic databases (MEDLINE, Cochrane Library and Goggle Scholar covering the period from 1980 to January 2012) and meta-analysis of relevant cross-sectional and longitudinal studies were conducted to assess the association of CKD and cognitive decline.

RESULTS

Most cross-sectional and longitudinal studies suggest an association between cognitive impairment and CKD. Meta-analysis of cross-sectional and longitudinal studies comprising 54,779 participants yielded an association of cognitive decline in patients with CKD compared with patients without CKD (OR 1.65, 95% CI 1.32-2.05; p < 0.001, and OR 1.39, 95% CI 1.15-1.68; p < 0.001, respectively).

CONCLUSION

This is the first meta-analysis assessing the impact of CKD on cognitive decline. Our results suggest CKD being a significant and independent somatic risk factor in the development of cognitive decline.

摘要

背景

慢性肾脏病（CKD）已成为认知障碍和痴呆的一个可能的新危险因素，但研究结果仍存在争议。

方法

对电子数据库（MEDLINE、Cochrane 图书馆和 Google Scholar，涵盖 1980 年至 2012 年 1 月期间）进行系统文献检索，并对相关横断面和纵向研究进行荟萃分析，以评估 CKD 和认知能力下降之间的关系。

结果

大多数横断面和纵向研究表明认知障碍与 CKD 之间存在关联。对包括 54779 名参与者的横断面和纵向研究进行荟萃分析得出，与无 CKD 的患者相比，CKD 患者的认知能力下降（OR 1.65，95%CI 1.32-2.05；p<0.001）和认知能力下降（OR 1.39，95%CI 1.15-1.68；p<0.001）分别存在关联。