通过不对称异硫脲催化的3-丁炔酸乙酯与迈克尔受体的（4+2）环加成反应合成3,4-二氢吡喃。
Asymmetric Isochalcogenourea-Catalyzed Synthesis of 3,4-Dihydropyrans via (4+2)-Cycloadditions of Ethyl But-3-ynoate with Michael Acceptors.
作者信息
Hofer Mario, Piringer Magdalena, Scheucher Anna, Vogl Lukas S, Waser Mario
机构信息
Institute of Organic Chemistry, Johannes Kepler University Linz, Altenbergerstrasse 69, 4040 Linz, Austria.
出版信息
Synlett. 2025 Aug 18. doi: 10.1055/a-2659-8340.
Abstract
We herein report the use of ethyl but-3-ynoate as a C2 building block for asymmetric (4+2)-heterocycloadditions with various Michael acceptors. Upon using chiral isochalcogenoureas as Lewis base catalysts, these reactions can be carried out with good to excellent control of the regioselectivity, diastereoselectivity, and enantioselectivity.
摘要
我们在此报道了使用3-丁炔酸乙酯作为C2结构单元，与各种迈克尔受体进行不对称(4+2)杂环加成反应。使用手性异硫脲作为路易斯碱催化剂时，这些反应能够以良好至优异的区域选择性、非对映选择性和对映选择性进行。
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