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本文引用的文献

1
Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial.腮腺保留调强放疗与常规放疗治疗头颈部肿瘤（PARSPORT）：一项 3 期多中心随机对照试验。
Lancet Oncol. 2011 Feb;12(2):127-36. doi: 10.1016/S1470-2045(10)70290-4. Epub 2011 Jan 12.
2
How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients?调强放疗与常规二维放疗对鼻咽癌患者治疗效果有何影响？
Int J Radiat Oncol Biol Phys. 2011 Jul 1;80(3):661-8. doi: 10.1016/j.ijrobp.2010.03.024. Epub 2010 Jul 17.
3
Positron emission tomography with [18F]fluorodeoxyglucose improves staging and patient management in patients with head and neck squamous cell carcinoma: a multicenter prospective study.正电子发射断层扫描与[18F]氟脱氧葡萄糖提高头颈部鳞状细胞癌患者的分期和患者管理：一项多中心前瞻性研究。
J Clin Oncol. 2010 Mar 1;28(7):1190-5. doi: 10.1200/JCO.2009.24.6298. Epub 2010 Feb 1.
4
Prognostic factors of 305 nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy.305例接受调强放射治疗的鼻咽癌患者的预后因素
Chin J Cancer. 2010 Feb;29(2):145-50. doi: 10.5732/cjc.009.10332.
5
Surviving hypopharynx-larynx carcinoma in the era of IMRT.调强放疗时代下咽-喉癌的生存。
Int J Radiat Oncol Biol Phys. 2010 Aug 1;77(5):1391-6. doi: 10.1016/j.ijrobp.2009.07.005. Epub 2010 Jan 7.
6
Correlation between dose to the pharyngeal constrictors and patient quality of life and late dysphagia following chemo-IMRT for head and neck cancer.头颈部癌症化放综合治疗后咽缩肌剂量与患者生活质量及迟发性吞咽困难的相关性。
Radiother Oncol. 2009 Dec;93(3):539-44. doi: 10.1016/j.radonc.2009.09.017. Epub 2009 Oct 31.
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Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology group phase II trial 0225.鼻咽癌调强放射治疗联合或不联合化疗：放射肿瘤学组II期试验0225
J Clin Oncol. 2009 Aug 1;27(22):3684-90. doi: 10.1200/JCO.2008.19.9109. Epub 2009 Jun 29.
8
Multi-institutional trial of accelerated hypofractionated intensity-modulated radiation therapy for early-stage oropharyngeal cancer (RTOG 00-22).多机构加速适形调强放疗治疗早期口咽癌的研究（RTOG 00-22）。
Int J Radiat Oncol Biol Phys. 2010 Apr;76(5):1333-8. doi: 10.1016/j.ijrobp.2009.04.011. Epub 2009 Jun 18.
9
Nasopharyngeal carcinoma treated with reduced-volume intensity-modulated radiation therapy: report on the 3-year outcome of a prospective series.采用缩野调强放射治疗的鼻咽癌：一项前瞻性系列研究的3年结果报告
Int J Radiat Oncol Biol Phys. 2009 Nov 15;75(4):1071-8. doi: 10.1016/j.ijrobp.2008.12.015. Epub 2009 Apr 11.
10
Volumetric intensity-modulated arc therapy vs. conventional IMRT in head-and-neck cancer: a comparative planning and dosimetric study.容积调强弧形放疗与传统调强放疗用于头颈癌治疗的比较：一项计划与剂量学对比研究
Int J Radiat Oncol Biol Phys. 2009 May 1;74(1):252-9. doi: 10.1016/j.ijrobp.2008.12.033.

头颈部癌症调强放疗的临床评估。

Clinical evaluation of intensity-modulated radiotherapy for head and neck cancers.

机构信息

Head and Neck Unit, Royal Marsden Hospital, Sutton, Surrey, UK.

出版信息

Br J Radiol. 2012 May;85(1013):487-94. doi: 10.1259/bjr/85942136.

DOI:10.1259/bjr/85942136
PMID:22556403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3479880/
Abstract

Radiotherapy and surgery are the principal curative modalities in treatment of head and neck cancer. Conventional two-dimensional and three-dimensional conformal radiotherapy result in significant side effects and altered quality of life. Intensity-modulated radiotherapy (IMRT) can spare the normal tissues, while delivering a curative dose to the tumour-bearing tissues. This article reviews the current role of IMRT in head and neck cancer from the point of view of normal tissue sparing, and also reviews the current published literature by individual head and neck cancer subsites. In addition, we briefly discuss the role of image guidance in head and neck IMRT, and future directions in this area.

摘要

放射治疗和手术是治疗头颈部癌症的主要方法。传统的二维和三维适形放射治疗会导致严重的副作用和生活质量下降。调强放疗（IMRT）可以保护正常组织，同时向肿瘤靶区提供治疗剂量。本文从保护正常组织的角度综述了 IMRT 在头颈部癌症中的作用，并按头颈部不同亚部位回顾了目前的文献。此外，我们还简要讨论了头颈部 IMRT 中图像引导的作用和该领域的未来发展方向。