一名患有双淋巴瘤的患者：同时患有胃黏膜相关淋巴组织淋巴瘤和回肠弥漫性大B细胞淋巴瘤。
One patient with double lymphomas: simultaneous gastric MALT lymphoma and ileal diffuse large B-cell lymphoma.
作者信息
Terada Tadashi
机构信息
Department of Pathology, Shizuoka City Shimizu Hospital Shizuoka, Japan.
出版信息
Int J Clin Exp Pathol. 2012;5(3):260-3. Epub 2012 Mar 25.
Abstract
Multiple different lymphomas in a single person are very rare. The author herein reports the case of a 69- year-old Japanese woman with double gastrointestinal lymphoma. The patient presented with epigastralgia. Endoscopic examination revealed erosions and elevation of the gastric body and a large ulcerated tumor of the terminal ileum. Biopsies were obtained from these lesions. The gastric lesion was MALT lymphoma with monocytoid B-cell proliferation and lymphoepithelial lesions. Light chain restriction was present. Helicobacter pylori were present on Giemsa stain. The gastric lesions did not regress despite of therapy, which were confirmed by follow-up biopsy. The ileal lesion was obvious diffuse large B-cell lymphoma. The lesion regressed by chemotherapy. The patient is now alive 3 years after the first presentation.
摘要
同一个人身上出现多种不同的淋巴瘤非常罕见。本文作者报告了一例69岁日本女性患双原发性胃肠道淋巴瘤的病例。患者表现为上腹部疼痛。内镜检查发现胃体有糜烂和隆起，回肠末端有一个大的溃疡性肿瘤。从这些病变部位取了活检样本。胃部病变为伴有单核样B细胞增殖和淋巴上皮病变的黏膜相关淋巴组织淋巴瘤。存在轻链限制。吉姆萨染色显示有幽门螺杆菌。尽管进行了治疗，但胃部病变并未消退，后续活检证实了这一点。回肠病变为明显的弥漫性大B细胞淋巴瘤。该病变经化疗后消退。患者自首次发病后已存活3年。
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