Mahadevan P R, Robinson P
Foundation for Medical Research, Worli, Bombay, India.
Trop Med Parasitol. 1990 Sep;41(3):310-3.
The delipidified cell components of Mycobacterium leprae (DCC) obtained as an insoluble material was presented as an antigen by the macrophages of lepromatous leprosy patients. This resulted in in vitro lymphocyte proliferation and production of lymphokines, like IL-2 and IFN-gamma. This DCC induced culture supernatant was capable of activating patient macrophages through changes induced in the membrane, as monitored by same specific markers, before and after exposure to the supernatant. The activated macrophages could recognise M. leprae as an antigen to initiate cell mediated immunity and also recognise the bacilli as a pathogen to produce superoxide leading to the killing of phagocytosed M. leprae. Based on these observations, it is indicated that DCC could be a potent immunomodulatory restoring in the phagocytes of leprosy patients to kill M. leprae like normal resistant individuals.
作为不溶性物质获得的麻风分枝杆菌脱脂细胞成分（DCC），由瘤型麻风患者的巨噬细胞呈递为抗原。这导致了体外淋巴细胞增殖以及细胞因子如白细胞介素-2和干扰素-γ的产生。这种DCC诱导的培养上清液能够通过膜上诱导的变化激活患者巨噬细胞，这在暴露于上清液前后通过相同的特异性标志物进行监测。活化的巨噬细胞能够将麻风分枝杆菌识别为抗原以启动细胞介导的免疫，并且还将杆菌识别为病原体以产生超氧化物，从而导致吞噬的麻风分枝杆菌被杀死。基于这些观察结果，表明DCC可能是一种有效的免疫调节剂，可恢复麻风患者吞噬细胞像正常抗性个体一样杀死麻风分枝杆菌的能力。
