Division of Endocrinology, Diabetes and Nutrition, Geneva University Hospital, 1206 Geneva, Switzerland.
Diabetes Metab. 2012 Oct;38(4):370-2. doi: 10.1016/j.diabet.2012.03.005. Epub 2012 May 3.
Hypothermia is a recognized complication of severe hypoglycaemia, but its prevalence and characteristics are poorly studied. For this reason, this study aimed to evaluate hypothermia in severely hypoglycaemic patients.
A retrospective chart review was performed including all patients discharged between 2007 and 2010 from the Emergency Department of the Geneva University Hospital with a diagnosis of severe hypoglycaemia.
Hypothermia was identified in 30 (23.4%) out of 128 patients with severe hypoglycaemia. Its incidence was not affected by age, type of diabetes, season or time of day (day/night). Using linear regression, the lowest recorded temperature was associated with the Glasgow coma scale (GCS) score (r2 = 13.8%, P < 0.0001) and inversely associated with the leukocyte count (r2 = 13.1%, P = 0.001).
Hypothermia is a frequent sign of severe hypoglycaemia in patients with diabetes. The associations between hypothermia and the GCS score and the leukocyte count suggest that it is a marker of hypoglycaemia severity and/or duration. Hypothermia may represent an important compensatory mechanism in severe hypoglycaemia, reflecting a decrease in energy demand during glucose deprivation.
低温是严重低血糖的一种公认并发症，但低温的患病率和特征研究甚少。因此，本研究旨在评估严重低血糖患者的低温情况。
对 2007 年至 2010 年间从日内瓦大学医院急诊科出院的所有严重低血糖诊断患者进行回顾性图表审查。
在 128 名严重低血糖患者中，有 30 名（23.4%）出现低温。其发病率不受年龄、糖尿病类型、季节或昼夜时间（白天/夜间）的影响。使用线性回归，记录到的最低温度与格拉斯哥昏迷量表（GCS）评分相关（r2 = 13.8%，P < 0.0001），与白细胞计数呈负相关（r2 = 13.1%，P = 0.001）。
低温是糖尿病患者严重低血糖的常见体征。低温与 GCS 评分和白细胞计数之间的关联表明，它是低血糖严重程度和/或持续时间的标志物。低温可能代表严重低血糖时的一个重要代偿机制，反映了葡萄糖剥夺期间能量需求的减少。
