Department of Dermatology, Venereology and Dermato-Oncology, Semmelweis University, Mária utca 41, Budapest 1085, Hungary.
Immunol Allergy Clin North Am. 2012 May;32(2):255-62, vi. doi: 10.1016/j.iac.2012.04.005. Epub 2012 Apr 17.
Dermatitis herpetiformis (DH) is characterized by chronic, itching papules, seropapules, small vesicles and, exceptionally, large blisters. The distribution of these polymorphic symptoms around the elbow, knee, buttock, and back is suggestive of the diagnosis. DH is further confirmed by the accumulation of granulocytes at the papillary dermis, resulting in a subepidermal split formation and by the presence of a unique, granular IgA precipitate in the uppermost dermis. Prognosis is predominantly determined by other autoimmune pathologies, malabsorption, or very rarely by lymphomas. Some of these diseases can be prevented by an early-onset, strict gluten-free diet, which is therefore the suggested treatment option.
疱疹样皮炎（DH）的特征为慢性、瘙痒性丘疹、血清丘疹、小水疱，偶尔出现大水疱。肘、膝、臀部和背部的这些多形性症状的分布提示了该疾病的诊断。DH 还可通过在乳头真皮层粒细胞的积累，导致表皮下分裂形成和在最上层真皮中存在独特的、颗粒状 IgA 沉淀而得到进一步确认。预后主要取决于其他自身免疫性病变、吸收不良或极少数情况下的淋巴瘤。这些疾病中的一些可以通过早期、严格的无麸质饮食来预防，因此这是建议的治疗选择。
