Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605 006, India.
Clin Biochem. 2012 Jul;45(10-11):835-8. doi: 10.1016/j.clinbiochem.2012.04.018. Epub 2012 Apr 27.
The objective of this study is to assess the association of blood and urinary oxidative stress parameters and inflammatory markers in women with gestational hypertension and preeclampsia.
Malondialdehyde, protein bound sialic acid and C-reactive protein were estimated in serum and urine of pregnant women diagnosed with preeclampsia (n=30) and gestational hypertension (n=30) and the results were compared with 30 normal pregnant women.
Whole blood glutathione level was reduced, and malondialdehyde and C-reactive protein levels were significantly higher and correlated with each other in preeclampsia (p<0.05). Urinary malondialdehyde significantly correlated with urinary protein bound sialic acid in preeclampsia (r=0.412; p=0.02). Receiver operating curve analysis of serum protein bound sialic acid and serum malondialdehyde showed reasonable cutoff values for the differential diagnosis of preeclampsia.
Oxidative stress and inflammatory response are greater in women with preeclampsia in comparison to pregnant women with gestational hypertension and there is an association between oxidative stress and inflammatory response.
本研究旨在评估妊娠期高血压和子痫前期妇女血液和尿液氧化应激参数及炎症标志物的相关性。
检测子痫前期（n=30）和妊娠期高血压（n=30）孕妇的血清和尿液中的丙二醛、蛋白结合唾液酸和 C 反应蛋白，并与 30 例正常孕妇进行比较。
全血谷胱甘肽水平降低，丙二醛和 C 反应蛋白水平显著升高，且两者呈正相关（p<0.05）。子痫前期患者尿丙二醛与尿蛋白结合唾液酸呈显著正相关（r=0.412；p=0.02）。血清蛋白结合唾液酸和血清丙二醛的受试者工作特征曲线分析显示，其对于子痫前期的鉴别诊断具有合理的临界值。
与妊娠期高血压孕妇相比，子痫前期妇女的氧化应激和炎症反应更为严重，且氧化应激与炎症反应之间存在关联。
