Sathish Babu Murugaiyan, Sreesoorya K P, Menon Surendra K, Saha Subiman, Srinivasan A R, Arul Vijaya Vani S, Reeta R, Kuzhandai Velu V
Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute Pillayarkuppam, Puducherry, 607402 India.
Department of Pulmonary Medicine, Mahatma Gandhi Medical College and Research Institute Pillayarkuppam, Puducherry, 607403 India.
Indian J Clin Biochem. 2017 Jun;32(2):225-229. doi: 10.1007/s12291-016-0595-4. Epub 2016 Jul 22.
Mortality and morbidity attributed to asthma remains to be the biggest nightmare worldwide. Hence, the study was aimed to compare the cardio metabolic risk factors as assessed by Body mass index (BMI), waist hip ratio (WHR), serum triacylglycerol and uric acid in well controlled and poorly controlled asthmatics and to correlate these parameters with the severity of asthma. A case control study was conducted on 90 subjects who were segregated into well controlled asthmatics (n = 30) and poorly controlled asthmatics (n = 30) who were diagnosed based on Global initiative for Asthma management guidelines and healthy volunteers (n = 30). Centrifuged fasting venous blood samples were used for biochemical analysis, pulmonary function test, BMI, and waist hip ratio (WHR) were measured. The statistical analysis was done using SPSS version 17. There was a significant increase in BMI, WHR, lipid profile, serum uric acid and decrease in forced expiratory volume (FEV1), forced vital capacity (FVC), and FEV1/FVC in poorly controlled asthmatics. There was a significant association between FEV1 and serum uric acid, BMI and Triacylgycerol in poorly controlled asthmatics. Poorly controlled asthmatics have greater risk of developing cardiometabolic problems. Serum uric acid can be used as one of the severity markers in asthma to assess cardio metabolic risk.
哮喘导致的死亡率和发病率仍是全球最大的噩梦。因此，本研究旨在比较通过体重指数（BMI）、腰臀比（WHR）、血清甘油三酯和尿酸评估的良好控制和控制不佳的哮喘患者的心脏代谢危险因素，并将这些参数与哮喘的严重程度相关联。对90名受试者进行了病例对照研究，这些受试者被分为根据全球哮喘防治创议管理指南诊断的良好控制的哮喘患者（n = 30）、控制不佳的哮喘患者（n = 30）和健康志愿者（n = 30）。采用离心后的空腹静脉血样进行生化分析，测量肺功能、BMI和腰臀比（WHR）。使用SPSS 17版进行统计分析。控制不佳的哮喘患者的BMI、WHR、血脂谱、血清尿酸显著升高，用力呼气量（FEV1）、用力肺活量（FVC）和FEV1/FVC降低。在控制不佳的哮喘患者中，FEV1与血清尿酸、BMI与甘油三酯之间存在显著关联。控制不佳的哮喘患者发生心脏代谢问题的风险更高。血清尿酸可作为哮喘严重程度的标志物之一，以评估心脏代谢风险。
