Department of Biochemistry, Istanbul University, Cerrahpasa Medical Faculty, Cerrahpasa, 34303 Istanbul, Turkey.
Arch Gynecol Obstet. 2011 Dec;284(6):1367-73. doi: 10.1007/s00404-011-1865-2. Epub 2011 Feb 23.
The aim of this study is to determine the predictive values of oxidative stress markers and antioxidants in the development of preeclampsia between 10-14 and also at 20-24 weeks of gestation, after the completion of vascular transformation.
Levels of oxidative stress parameters such as malondialdehyde (MDA), lipidhydroperoxide (LHP) and prostaglandin F(2α) (PGF(2α)), oxidized LDL (oxLDL), and antioxidant status parameters such as paraoxonase 1 (PON1), superoxide dismutase (SOD) and total antioxidant capacity (TAC) levels were measured and compared in 21 preeclamptic and 24 healthy pregnant women.
In preeclamptic women, both between 10-14 and also at 20-24 weeks of gestation the levels of oxLDL, MDA and PGF(2α) were significantly higher (P < 0.001, P < 0.001, respectively), PON1, SOD and TAC were significantly lower (P < 0.01, P < 0.001, P < 0.05, respectively) compared to healthy pregnant women; yet there was no significant difference in LHP levels.
Increased levels of serum MDA and PGF(2α), low levels of SOD and PON1 activity, in 10-14 GW may have been associated with preeclampsia etiology. High levels of MDA and PGF(2α) indicate that the oxidative damage is present well before the clinical symptoms occur. A panel of oxidative stress markers such as MDA and PGF(2α) in maternal blood can predict the development of preeclampsia long before clinical onset.
本研究旨在确定氧化应激标志物和抗氧化剂在血管转化完成后 10-14 周和 20-24 周妊娠时预测子痫前期发生的价值。
测量并比较了 21 例子痫前期和 24 例健康孕妇的氧化应激参数（如丙二醛（MDA）、脂质过氧化物（LHP）和前列腺素 F（2α）（PGF（2α））、氧化型低密度脂蛋白（oxLDL））和抗氧化状态参数（如对氧磷酶 1（PON1）、超氧化物歧化酶（SOD）和总抗氧化能力（TAC））水平。
在子痫前期妇女中，10-14 周和 20-24 周时 oxLDL、MDA 和 PGF（2α）水平显著升高（P<0.001，P<0.001），PON1、SOD 和 TAC 水平显著降低（P<0.01，P<0.001，P<0.05），与健康孕妇相比；然而，LHP 水平没有显著差异。
10-14 周时血清 MDA 和 PGF（2α）水平升高、SOD 和 PON1 活性降低，可能与子痫前期的病因有关。MDA 和 PGF（2α）水平升高表明氧化损伤在临床症状出现之前就已经存在。母体血液中的一组氧化应激标志物，如 MDA 和 PGF（2α），可以在临床症状出现之前很长时间预测子痫前期的发生。
