Unit of Lung Biology, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Pulm Pharmacol Ther. 2013 Feb;26(1):13-23. doi: 10.1016/j.pupt.2012.04.003. Epub 2012 Apr 28.
Smooth muscle comprises a key functional component of both the airways and their supporting vasculature. Dysfunction of smooth muscle contributes to and exacerbates a host of breathing-associated pathologies such as asthma, chronic obstructive pulmonary disease and pulmonary hypertension. These diseases may be marked by airway and/or vascular smooth muscle hypertrophy, proliferation and hyper-reactivity, and related conditions such as fibrosis and extracellular matrix remodeling. This review will focus on the contribution of airway or vascular smooth dysfunction to common airway diseases.
平滑肌是气道及其支持血管的关键功能组成部分。平滑肌功能障碍会导致并加重许多与呼吸相关的疾病，如哮喘、慢性阻塞性肺疾病和肺动脉高压。这些疾病的特征可能是气道和/或血管平滑肌肥大、增殖和高反应性，以及相关的病症，如纤维化和细胞外基质重塑。这篇综述将重点讨论气道或血管平滑肌功能障碍对常见气道疾病的贡献。
