Burgio G R
Paediatric Department, University of Pavia, Italy.
Thymus. 1990 Sep;16(2):99-117.
Starting from the conceptual premises of Garrod, who as long ago as 1902 spoke of "chemical individuality", and of Burnet (1949), who recognized as self one's own molecular antigenic structures (as opposed to the antigenic "alien": the non-self), the discovery and understanding of HLA antigens and of their extraordinarily individual and differentiated polymorphisms have gained universal recognition. Transplant medicine has now dramatically stressed, within man's knowledge of himself, the characteristic of his "biological uniqueness". Today man, having become aware of being a biological antigenic-molecular individuality which is unique and different from that of all of his fellow men (except for monozygotic twins), can therefore easily consider himself a true "biological Ego".
早在1902年，加罗德就提出了“化学个体性”的概念前提；1949年，伯内特认识到自身的分子抗原结构（与抗原性“异己”：非自身相对）。从这些概念前提出发，人类对HLA抗原及其极其独特和分化的多态性的发现与理解已得到普遍认可。移植医学如今已在人类对自身的认知中，大力强调了人类“生物独特性”这一特征。如今，人类已意识到自己是一种独特的生物抗原分子个体，与其他所有人（除同卵双胞胎外）都不同，因此很容易将自己视为一个真正的“生物自我”。
